Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 7/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14728375 | 0.85 | PIK3CB (0.38) | PIK3CBPIK3CDPIK3CACCR2CCR5 | |
| SCHEMBL14728249 | 0.81 | CCR2 (0.32) | PIK3CBPIK3CDPIK3CACCR2CCR5 | |
| SCHEMBL15843942 | 0.75 | PIK3CB (0.56) | PIK3CBPIK3CDPIK3CACCR2CCR5 | |
| SCHEMBL14728405 | 0.75 | PIK3CD (0.35) | PIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL14728235 | 0.73 | ADCY10 (0.31) | CCR2 | |
| SCHEMBL14728548 | 0.66 | PIK3CB (0.32) | PIK3CBPIK3CDPIK3CG | |
| SCHEMBL15844032 | 0.59 | PIK3CB (0.63) | PIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL14720556 | 0.56 | PNMT (0.41) | PIK3CBPIK3CDPIK3CACCR2CCR5 | |
| SCHEMBL14411093 | 0.56 | ADCY10 (0.35) | — | |
| SCHEMBL13818593 | 0.55 | GABRA1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013028263-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-02-28 | — | — | WO | disclosed |