Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 14/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nerandomilast SCHEMBL25606332 | 1.00 | PIK3R1 (0.34) | PIK3R1PIK3CA | |
| SCHEMBL30678851 | 0.96 | PIK3R1 (0.33) | PIK3R1PIK3CA | |
| SCHEMBL31083968 | 0.95 | PIK3R1 (0.32) | PIK3R1PIK3CA | |
| SCHEMBL25606343 | 0.92 | PIK3CA (0.34) | PIK3R1PIK3CA | |
| SCHEMBL31438838 | 0.92 | PIK3CA (0.37) | PIK3R1PIK3CA | |
| SCHEMBL31084026 | 0.92 | — | — | |
| SCHEMBL31084045 | 0.90 | PIK3R1 (0.30) | PIK3R1PIK3CA | |
| SCHEMBL31169291 | 0.87 | PIK3R1 (0.31) | PIK3R1PIK3CA | |
| SCHEMBL14734249 | 0.87 | MMP2 (0.32) | PIK3R1PIK3CA | |
| SCHEMBL31571879 | 0.85 | PIK3R1 (0.32) | PIK3R1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140228286-A1 | SPECIFIC PDE4B-INHIBITORS FOR THE TREATMENT OF DIABETES MELLITUS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-08-14 | — | — | US | claimed |
| US-11813266-B2 | Combination of active agents for the treatment of progressive fibrosing interstitial lung diseases (PF-ILD) | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2023-11-14 | — | — | US | disclosed |
| US-20230190754-A1 | Therapeutic combinations for the treatment of Progressive Fibrosing interstitial lung diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2023-06-22 | — | — | US | disclosed |
| US-20230181590-A1 | New oral pharmaceutical composition and dose regimen for the therapy of progressive fibrosing interstitial lung diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2023-06-15 | — | — | US | disclosed |
| US-10745411-B2 | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-08-18 | — | — | US | disclosed |
| US-20200048278-A1 | NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA | BOEHRINGER INGELHEIM INT (DE) | 2020-02-13 | — | — | US | disclosed |
| US-20190134043-A1 | New Combination of active agents for the treatment of Progressive Fibrosing Interstitial Lung Diseases (PF-ILD) | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-05-09 | — | — | US | disclosed |
| US-20180072754-A1 | NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA | BOEHRINGER INGELHEIM INT (DE) | 2018-03-15 | — | — | US | disclosed |
| US-20180072754-A1 | NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA | BOEHRINGER INGELHEIM INT (DE) | 2018-03-15 | — | — | US | disclosed |
| US-9802954-B2 | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-10-31 | — | — | US | disclosed |
| US-20150045376-A1 | NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-12 | — | — | US | disclosed |
| WO-2014124860-A1 | SPECIFIC PDE4B-INHIBITORS FOR THE TREATMENT OF DIABETES MELLITUS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-08-21 | — | — | WO | disclosed |
| US-20140228286-A1 | SPECIFIC PDE4B-INHIBITORS FOR THE TREATMENT OF DIABETES MELLITUS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-08-14 | — | — | US | disclosed |
| US-20140228286-A1 | SPECIFIC PDE4B-INHIBITORS FOR THE TREATMENT OF DIABETES MELLITUS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-08-14 | — | — | US | disclosed |
| US-20140228286-A1 | SPECIFIC PDE4B-INHIBITORS FOR THE TREATMENT OF DIABETES MELLITUS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-08-14 | — | — | US | disclosed |
| US-20130079359-A1 | NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-03-28 | — | — | US | disclosed |
| US-20130079359-A1 | NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-03-28 | — | — | US | disclosed |
| US-20130059866-A1 | NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-03-07 | — | — | US | disclosed |
| US-20130059866-A1 | NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-03-07 | — | — | US | disclosed |
| WO-2013026797-A1 | NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048278-A1 | NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA | CBS, CYSLTR1, DHPS | PIK3R1 3712/4885PIK3CA 3006/4885 |
| US-11813266-B2 | Combination of active agents for the treatment of progressive fibrosing interstitial lung diseases (PF-ILD) | PDE3B, PDE4B, PF4 | PIK3R1 971/4885PIK3CA 1177/4885 |
| US-20180072754-A1 | NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA | CBS, CYSLTR1, DHPS | PIK3R1 3712/4885PIK3CA 3006/4885 |
| US-10745411-B2 | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma | CBS, DHPS, TPMT | PIK3R1 3920/4885PIK3CA 3227/4885 |
| US-20130079359-A1 | NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA | CBS, SQOR, TST | PIK3R1 3521/4885PIK3CA 3256/4885 |
| US-20190134043-A1 | New Combination of active agents for the treatment of Progressive Fibrosing Interstitial Lung Diseases (PF-ILD) | PDE4B, PDE3B, PF4 | PIK3R1 1343/4885PIK3CA 1436/4885 |
| US-20230190754-A1 | Therapeutic combinations for the treatment of Progressive Fibrosing interstitial lung diseases | PDE4B, PDE3B, ACVR2B | PIK3R1 2051/4885PIK3CA 398/4885 |
| US-20140228286-A1 | SPECIFIC PDE4B-INHIBITORS FOR THE TREATMENT OF DIABETES MELLITUS | PDE4B, PDE3B, PDE4A | PIK3R1 2822/4885PIK3CA 927/4885 |
| US-20230181590-A1 | New oral pharmaceutical composition and dose regimen for the therapy of progressive fibrosing interstitial lung diseases | PDE3B, PDE4B, PDE3A | PIK3R1 2168/4885PIK3CA 703/4885 |
| US-20130059866-A1 | NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA | CBS, SQOR, TST | PIK3R1 3521/4885PIK3CA 3256/4885 |
| US-20150045376-A1 | NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA | CBS, CYSLTR1, DHPS | PIK3R1 3712/4885PIK3CA 3006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.