Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.37 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14659369 | 0.92 | PARP14 (0.42) | PARP14OPRK1KCNH2ACHEOPRM1 | |
| SCHEMBL15310356 | 0.88 | OPRK1 (0.43) | SIRT2SIRT1SIRT3PARP14OPRK1 | |
| SCHEMBL15310322 | 0.87 | PARP1 (0.41) | PARP14SMN1; SMN2 | |
| SCHEMBL14734963 | 0.86 | PARP1 (0.41) | PARP14SMN1; SMN2 | |
| SCHEMBL15310418 | 0.84 | KCNH2 (0.38) | PARP14OPRK1KCNH2ACHEMGLL | |
| SCHEMBL1532764 | 0.76 | FAAH (0.49) | SIRT2SIRT1SIRT3PARP14OPRK1 | |
| SCHEMBL1532785 | 0.74 | OPRM1 (0.44) | PARP14OPRK1KCNH2OPRM1OPRD1 | |
| SCHEMBL15310405 | 0.74 | ACHE (0.46) | PARP14ACHEOPRM1OPRD1 | |
| SCHEMBL15310414 | 0.68 | PARP14 (0.60) | PARP14OPRK1KCNH2ACHEOPRM1 | |
| SCHEMBL1532748 | 0.67 | FAAH (0.54) | SIRT2SIRT1SIRT3PARP14OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1849773-B1 | Piperazine derivatives for the treatment of urinary incontinence and pain | ASTELLAS PHARMA INC (JP) | 2013-10-16 | — | — | EP | claimed |
| EP-2564849-A1 | PROPHYLACTIC OR THERAPEUTIC AGENT FOR DISEASES ASSOCIATED WITH PAINS IN URINARY ORGANS | Astellas Pharma Inc. (JP) | 2013-03-06 | — | — | EP | disclosed |