Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15310322 | 0.99 | PARP1 (0.41) | PARP1KDM1AALDH1A1PARP14RAB9A | |
| SCHEMBL14659369 | 0.92 | PARP14 (0.42) | PARP1KDM1APARP14 | |
| SCHEMBL15310356 | 0.87 | OPRK1 (0.43) | PARP14 | |
| SCHEMBL14734880 | 0.86 | SIRT2 (0.37) | PARP14SMN1; SMN2 | |
| SCHEMBL15310418 | 0.83 | KCNH2 (0.38) | KDM1APARP14 | |
| SCHEMBL1532863 | 0.77 | FAAH (0.49) | PARP1ALDH1A1PARP14RAB9ANPC1 | |
| SCHEMBL1532872 | 0.76 | FAAH (0.50) | PARP1ALDH1A1PARP14RAB9ANPC1 | |
| SCHEMBL15310277 | 0.75 | L3MBTL3 (0.49) | ALDH1A1RAB9ANPC1SMN1; SMN2PKM | |
| SCHEMBL15310435 | 0.74 | L3MBTL3 (0.50) | ALDH1A1RAB9ANPC1SMN1; SMN2PKM | |
| SCHEMBL1532785 | 0.73 | OPRM1 (0.44) | PARP1KDM1APARP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1849773-B1 | Piperazine derivatives for the treatment of urinary incontinence and pain | ASTELLAS PHARMA INC (JP) | 2013-10-16 | — | — | EP | claimed |
| EP-2564849-A1 | PROPHYLACTIC OR THERAPEUTIC AGENT FOR DISEASES ASSOCIATED WITH PAINS IN URINARY ORGANS | Astellas Pharma Inc. (JP) | 2013-03-06 | — | — | EP | disclosed |