Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 13/20 | 0.74 |
| ▸ | ABCG2 | Q9UNQ0 | 8/20 | 0.74 |
| ▸ | DHCR7 | Q9UBM7 | 3/20 | 0.72 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.56 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14740406 | 0.94 | ABCB1 (0.66) | ABCB1ABCG2DHCR7ABCC1 | |
| SCHEMBL8789531 | 0.92 | ABCB1 (0.81) | ABCB1ABCG2DHCR7KCNJ1KCNH2 | |
| Hydrochloric Acid SCHEMBL10659282 | 0.91 | ABCB1 (0.80) | ABCB1ABCG2DHCR7KCNJ1KCNH2 | |
| SCHEMBL14740471 | 0.90 | DHCR7 (0.73) | ABCB1ABCG2DHCR7ABCC1 | |
| Hydrochloric Acid SCHEMBL11382753 | 0.86 | ABCB1 (0.71) | ABCB1ABCG2KCNJ1KCNH2 | |
| SCHEMBL8790054 | 0.85 | ABCB1 (0.71) | ABCB1ABCG2ABCC1 | |
| SCHEMBL3042454 | 0.85 | DHCR7 (0.81) | ABCB1ABCG2DHCR7ABCC1 | |
| SCHEMBL17664978 | 0.84 | ABCB1 (0.69) | ABCB1ABCG2DHCR7KCNJ1KCNH2 | |
| Hydrochloric Acid SCHEMBL11280074 | 0.84 | ABCB1 (0.71) | ABCB1ABCG2ABCC1KCNJ1KCNH2 | |
| SCHEMBL17664977 | 0.84 | DHCR7 (0.79) | ABCB1ABCG2DHCR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3589626-B1 | 8-PHENYL-ISOQUINOLINES AND PHARMACEUTICAL COMPOSITION THEREOF USED IN THE TREATMENT OF IRRITABLE BOWEL SYNDROME | UNIV NAT TAIWAN (TW) | 2024-06-12 | — | — | EP | disclosed |
| CN-116964044-A | Acetamido-phenyltetrazole derivatives and methods of use thereof | 希华医药有限公司 | 2023-10-27 | — | — | CN | disclosed |
| US-11739089-B2 | Acetamido-phenyltetrazole derivatives and methods of using the same | ATHENEX, INC. (US) | 2023-08-29 | — | — | US | disclosed |
| US-11739089-B2 | Acetamido-phenyltetrazole derivatives and methods of using the same | ATHENEX, INC. (US) | 2023-08-29 | — | — | US | disclosed |
| EP-4225747-A1 | ACETAMIDO-PHENYLTETRAZOLE DERIVATIVES AND METHODS OF USING THE SAME | Athenex, Inc. (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076663-A1 | ACETAMIDO-PHENYLTETRAZOLE DERIVATIVES AND METHODS OF USING THE SAME | ATHENEX, INC. (US) | 2022-04-14 | — | — | WO | disclosed |
| US-20220106312-A1 | ACETAMIDO-PHENYLTETRAZOLE DERIVATIVES AND METHODS OF USING THE SAME | Health Hope Pharma Limited (HK) | 2022-04-07 | — | — | US | disclosed |
| US-20200071274-A1 | 8-PHENYL-ISOQUINOLINES AND PHARMACEUTICAL COMPOSITION THEREOF USED IN THE TREATMENT OF IRRITABLE BOWEL SYNDROME | NATIONAL TAIWAN UNIVERSITY (TW) | 2020-03-05 | — | — | US | disclosed |
| US-8552028-B2 | 8-phenylisoquinolines and pharmaceutical composition used in treatment for sepsis | NATIONAL TAIWAN UNIVERSITY (TW) | 2013-10-08 | — | — | US | disclosed |
| US-20130059882-A1 | 8-Phenylisoquinolines And Pharmaceutical Composition Used In Treatment For Sepsis | NATIONAL TAIWAN UNIVERSITY (TW) | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220106312-A1 | ACETAMIDO-PHENYLTETRAZOLE DERIVATIVES AND METHODS OF USING THE SAME | ABCB1, CYP3A5, CYP3A7 | ABCB1 1/4885ABCG2 18/4885DHCR7 332/4885 |
| US-20130059882-A1 | 8-Phenylisoquinolines And Pharmaceutical Composition Used In Treatment For Sepsis | CXCL8, THPO, IL18 | ABCB1 275/4885ABCG2 1385/4885DHCR7 760/4885 |
| US-20200071274-A1 | 8-PHENYL-ISOQUINOLINES AND PHARMACEUTICAL COMPOSITION THEREOF USED IN THE TREATMENT OF IRRITABLE BOWEL SYNDROME | HTR7, GPR27, HTR5A | ABCB1 328/4885ABCG2 136/4885DHCR7 1398/4885 |
| US-11739089-B2 | Acetamido-phenyltetrazole derivatives and methods of using the same | ABCB1, CYP3A5, CYP3A7 | ABCB1 1/4885ABCG2 18/4885DHCR7 332/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.