Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.37 |
| ▸ | PDE4A | P27815 | 9/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.36 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14740066 | 0.92 | PDE4B (0.40) | MAPK14PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL18622354 | 0.88 | PDE4B (0.36) | MAPK14PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL14740391 | 0.86 | PDE4B (0.38) | MAPK14PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL14740191 | 0.85 | NR1I3 (0.43) | — | |
| SCHEMBL14739677 | 0.84 | L3MBTL1 (0.40) | MAPK14PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL14740209 | 0.77 | DPP4 (0.43) | — | |
| SCHEMBL14740076 | 0.74 | LMNA (0.43) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL18622362 | 0.73 | NR1I3 (0.44) | — | |
| SCHEMBL4563977 | 0.73 | HSD11B1 (0.45) | — | |
| SCHEMBL14739276 | 0.72 | NR1I3 (0.43) | MAPK14MAPK13MAPK12MAPK11PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9593109-B2 | Bicyclic agonists of GPR131 and uses thereof | CYMABAY THERAPEUTICS, INC. (US) | 2017-03-14 | — | — | US | claimed |
| US-20130059845-A1 | BICYCLIC AGONISTS OF GPR131 AND USES THEREOF | METABOLEX, INC. | 2013-03-07 | — | — | US | claimed |
| WO-2013032939-A1 | BICYCLIC AGONISTS OF GPR131 AND USES THEREOF | METABOLEX, INC. (US) | 2013-03-07 | — | — | WO | claimed |
| US-9593109-B2 | Bicyclic agonists of GPR131 and uses thereof | CYMABAY THERAPEUTICS, INC. (US) | 2017-03-14 | — | — | US | disclosed |
| US-9593109-B2 | Bicyclic agonists of GPR131 and uses thereof | CYMABAY THERAPEUTICS, INC. (US) | 2017-03-14 | — | — | US | disclosed |
| US-9593109-B2 | Bicyclic agonists of GPR131 and uses thereof | CYMABAY THERAPEUTICS, INC. (US) | 2017-03-14 | — | — | US | disclosed |
| US-20130059845-A1 | BICYCLIC AGONISTS OF GPR131 AND USES THEREOF | METABOLEX, INC. | 2013-03-07 | — | — | US | disclosed |
| US-20130059845-A1 | BICYCLIC AGONISTS OF GPR131 AND USES THEREOF | METABOLEX, INC. | 2013-03-07 | — | — | US | disclosed |
| WO-2013032939-A1 | BICYCLIC AGONISTS OF GPR131 AND USES THEREOF | METABOLEX, INC. (US) | 2013-03-07 | — | — | WO | disclosed |
| WO-2013033270-A2 | BROMODOMAIN LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME | COFERON, INC. (US) | 2013-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059845-A1 | BICYCLIC AGONISTS OF GPR131 AND USES THEREOF | GPR119, GPR88, GPR3 | MAPK14 1863/4885PDE4B 358/4885PDE4D 284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.