Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHCR7 | Q9UBM7 | 3/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.57 |
| ▸ | HTR2A | P28223 | 2/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | HTR7 | P34969 | 1/20 | 0.57 |
| ▸ | HRH1 | P35367 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.50 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30933428 | 1.00 | DHCR7 (0.60) | DHCR7SLC6A4HTR2AHTR1ADRD2 | |
| SCHEMBL14739801 | 0.83 | DHCR7 (0.64) | DHCR7DRD2DRD3ABCB1ABCC1 | |
| SCHEMBL14740355 | 0.81 | DHCR7 (0.64) | DHCR7DRD2DRD3ABCB1ABCC1 | |
| SCHEMBL14739336 | 0.81 | DHCR7 (0.69) | DHCR7DRD2DRD3ABCB1ABCC1 | |
| SCHEMBL3504140 | 0.80 | DHCR7 (0.79) | DHCR7DRD2DRD3ABCB1 | |
| SCHEMBL734941 | 0.80 | HTR2A (0.85) | SLC6A4HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL14739964 | 0.79 | HTR1A (0.49) | DHCR7SLC6A4HTR2AHTR1ADRD2 | |
| SCHEMBL14739533 | 0.78 | ABCB1 (0.60) | DHCR7DRD2DRD3ABCB1ABCC1 | |
| SCHEMBL10647034 | 0.77 | HTR1A (0.55) | SLC6A4HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL14740404 | 0.76 | DHCR7 (0.74) | DHCR7DRD2DRD3ABCB1ABCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3589626-B1 | 8-PHENYL-ISOQUINOLINES AND PHARMACEUTICAL COMPOSITION THEREOF USED IN THE TREATMENT OF IRRITABLE BOWEL SYNDROME | UNIV NAT TAIWAN (TW) | 2024-06-12 | — | — | EP | disclosed |
| US-20200071274-A1 | 8-PHENYL-ISOQUINOLINES AND PHARMACEUTICAL COMPOSITION THEREOF USED IN THE TREATMENT OF IRRITABLE BOWEL SYNDROME | NATIONAL TAIWAN UNIVERSITY (TW) | 2020-03-05 | — | — | US | disclosed |
| US-8552028-B2 | 8-phenylisoquinolines and pharmaceutical composition used in treatment for sepsis | NATIONAL TAIWAN UNIVERSITY (TW) | 2013-10-08 | — | — | US | disclosed |
| US-20130059882-A1 | 8-Phenylisoquinolines And Pharmaceutical Composition Used In Treatment For Sepsis | NATIONAL TAIWAN UNIVERSITY (TW) | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059882-A1 | 8-Phenylisoquinolines And Pharmaceutical Composition Used In Treatment For Sepsis | CXCL8, THPO, IL18 | DHCR7 760/4885SLC6A4 4125/4885HTR2A 2413/4885 |
| US-20200071274-A1 | 8-PHENYL-ISOQUINOLINES AND PHARMACEUTICAL COMPOSITION THEREOF USED IN THE TREATMENT OF IRRITABLE BOWEL SYNDROME | HTR7, GPR27, HTR5A | DHCR7 1398/4885SLC6A4 233/4885HTR2A 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.