Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ERCC1 | P07992 | 4/20 | 0.45 |
| ▸ | ERCC4 | Q92889 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | RHEB | Q15382 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14739660 | 0.82 | MEN1 (0.54) | ALDH1A1RHEBMEN1KMT2AMAPT | |
| SCHEMBL7714854 | 0.80 | KMT2A (0.57) | ALDH1A1POLBRHEBMEN1KMT2A | |
| SCHEMBL7708630 | 0.79 | KMT2A (0.56) | ALDH1A1RHEBMEN1KMT2AMAPT | |
| SCHEMBL2594688 | 0.78 | SLC6A4 (0.43) | ALDH1A1RHEB | |
| SCHEMBL14753482 | 0.75 | MAPT (0.43) | ALDH1A1RHEBMEN1KMT2AMAPT | |
| SCHEMBL2595477 | 0.75 | TUBB4A (0.54) | ALDH1A1MEN1KMT2A | |
| SCHEMBL14753480 | 0.74 | MAPT (0.45) | ALDH1A1POLBRHEBMEN1KMT2A | |
| SCHEMBL14738840 | 0.73 | MEN1 (0.40) | ALDH1A1RHEBMEN1KMT2AMAPT | |
| SCHEMBL14753481 | 0.73 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2AMAPTTSHR | |
| SCHEMBL14753478 | 0.73 | NUDT1 (0.41) | ALDH1A1NPC1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130059850-A1 | AZA-INDOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME CORP. (US) | 2013-03-07 | — | — | US | claimed |
| CN-102917707-A | Azaindole derivatives useful as modulators of FAAH | MERCK SHARP & DOHME | 2013-02-06 | — | — | CN | claimed |
| US-20130059850-A1 | AZA-INDOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME CORP. (US) | 2013-03-07 | — | — | US | disclosed |
| US-20130059850-A1 | AZA-INDOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME CORP. (US) | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059850-A1 | AZA-INDOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | FAAH, FAAH2, IDO1 | ALDH1A1 1530/4885ERCC1 4144/4885ERCC4 4415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.