Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 6/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.41 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.41 |
| ▸ | MAP2 | P11137 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30321020 | 1.00 | RORC (0.45) | RORCALOX5APFEN1SCN10APLA2G7 | |
| SCHEMBL14744206 | 0.88 | PLA2G7 (0.45) | RORCALOX5APFEN1SCN10APLA2G7 | |
| SCHEMBL19199851 | 0.83 | RORC (0.47) | RORCSCN9A | |
| SCHEMBL14744202 | 0.83 | RORC (0.50) | RORCMAP2 | |
| SCHEMBL30320910 | 0.83 | RORC (0.50) | RORCMAP2 | |
| SCHEMBL24032682 | 0.81 | POLB (0.62) | RORCALOX5APFEN1SCN10APDK2 | |
| SCHEMBL30320923 | 0.81 | POLB (0.62) | RORCALOX5APFEN1SCN10APDK2 | |
| SCHEMBL14744501 | 0.79 | ALOX5AP (0.43) | RORCALOX5APFEN1SCN10AMAP2 | |
| SCHEMBL30026285 | 0.78 | PLA2G7 (0.41) | RORCPLA2G7CYP3A4NFKB1PMP22 | |
| SCHEMBL30140163 | 0.78 | CYP3A4 (0.46) | CYP3A4SCN9AGRIN2BTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3476829-B1 | BIARYL UREA DERIVATIVE OR SALT THEREOF, AND MANUFACTURING AND APPLICATION OF SAME | UNIV FUDAN (CN) | 2021-12-15 | — | — | EP | disclosed |
| WO-2021228215-A1 | BIARYL COMPOUND CAPABLE OF SERVING AS RORγ REGULATOR | 上海辉启生物医药科技有限公司 | 2021-11-18 | — | — | WO | disclosed |
| US-10881649-B2 | Therapeutic agent or preventive agent for alopecia areata | TORAY INDUSTRIES, INC. (JP) | 2021-01-05 | — | — | US | disclosed |
| US-10881649-B2 | Therapeutic agent or preventive agent for alopecia areata | TORAY INDUSTRIES, INC. (JP) | 2021-01-05 | — | — | US | disclosed |
| US-10851050-B2 | Biaryl urea derivative or salt thereof and preparation process and use for the same | FUDAN UNIVERSITY (CN) | 2020-12-01 | — | — | US | disclosed |
| US-20200239411-A1 | BIARYL UREA DERIVATIVE OR SALT THEREOF AND PREPARATION PROCESS AND USE FOR THE SAME | UNIV FUDAN (CN) | 2020-07-30 | — | — | US | disclosed |
| US-20200215046-A1 | THERAPEUTIC AGENT OR PREVENTIVE AGENT FOR ALOPECIA AREATA | TORAY INDUSTRIES, INC. (JP) | 2020-07-09 | — | — | US | disclosed |
| US-20200215046-A1 | THERAPEUTIC AGENT OR PREVENTIVE AGENT FOR ALOPECIA AREATA | TORAY INDUSTRIES, INC. (JP) | 2020-07-09 | — | — | US | disclosed |
| EP-3409660-B1 | CYCLIC AMINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | TORAY INDUSTRIES (JP) | 2020-07-01 | — | — | EP | disclosed |
| EP-3409660-B1 | CYCLIC AMINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | TORAY INDUSTRIES (JP) | 2020-07-01 | — | — | EP | disclosed |
| US-20190248737-A1 | BIARYL UREA DERIVATIVE OR SALT THEREOF AND PREPARATION PROCESS AND USE FOR THE SAME | FUDAN UNIVERSITY (CN) | 2019-08-15 | — | — | US | disclosed |
| US-10364222-B2 | Cyclic amine derivative and medical use thereof | TORAY INDUSTRIES, INC. (JP) | 2019-07-30 | — | — | US | disclosed |
| US-10364222-B2 | Cyclic amine derivative and medical use thereof | TORAY INDUSTRIES, INC. (JP) | 2019-07-30 | — | — | US | disclosed |
| EP-3476829-A1 | BIARYL UREA DERIVATIVE OR SALT THEREOF, AND MANUFACTURING AND APPLICATION OF SAME | Fudan University (CN) | 2019-05-01 | — | — | EP | disclosed |
| WO-2019022235-A1 | THERAPEUTIC AGENT OR PROPHYLACTIC AGENT FOR ALOPECIA AREATA | 東レ株式会社 | 2019-01-31 | — | — | WO | disclosed |
| WO-2019022234-A1 | INFLAMMATORY BOWEL DISEASE THERAPEUTIC AGENT OR PROPHYLACTIC AGENT | 東レ株式会社 | 2019-01-31 | — | — | WO | disclosed |
| US-20180370916-A1 | CYCLIC AMINE DERIVATIVE AND MEDICAL USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 2018-12-27 | — | — | US | disclosed |
| EP-3409660-A1 | CYCLIC AMINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | Toray Industries, Inc. (JP) | 2018-12-05 | — | — | EP | disclosed |
| WO-2017131156-A1 | CYCLIC AMINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | 東レ株式会社 | 2017-08-03 | — | — | WO | disclosed |
| WO-2013029338-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2013-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200215046-A1 | THERAPEUTIC AGENT OR PREVENTIVE AGENT FOR ALOPECIA AREATA | RORA, RORB, RORC | RORC 3/4885ALOX5AP 682/4885FEN1 3452/4885 |
| US-20180370916-A1 | CYCLIC AMINE DERIVATIVE AND MEDICAL USE THEREOF | RORC, RORB, HRH3 | RORC 1/4885ALOX5AP 1148/4885FEN1 4733/4885 |
| US-10364222-B2 | Cyclic amine derivative and medical use thereof | RORC, RORB, HRH3 | RORC 1/4885ALOX5AP 1148/4885FEN1 4733/4885 |
| US-20200239411-A1 | BIARYL UREA DERIVATIVE OR SALT THEREOF AND PREPARATION PROCESS AND USE FOR THE SAME | RORC, RORB, RORA | RORC 1/4885ALOX5AP 3712/4885FEN1 4837/4885 |
| US-10881649-B2 | Therapeutic agent or preventive agent for alopecia areata | RORA, RORB, RORC | RORC 3/4885ALOX5AP 682/4885FEN1 3452/4885 |
| US-20190248737-A1 | BIARYL UREA DERIVATIVE OR SALT THEREOF AND PREPARATION PROCESS AND USE FOR THE SAME | RORC, RORB, RORA | RORC 1/4885ALOX5AP 3753/4885FEN1 4843/4885 |
| US-10851050-B2 | Biaryl urea derivative or salt thereof and preparation process and use for the same | RORC, RORB, RORA | RORC 1/4885ALOX5AP 3712/4885FEN1 4837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.