SCHEMBL147454

SCHEMBL147454

COc1cc(OC)c2c(=O)[nH]c(-c3cc(C)c(OCCO)c(C)c3)nc2n1

nearest known ligand 0.56

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 15/20 0.56
HDAC1 Q13547 4/20 0.52
HDAC2 Q92769 3/20 0.51
HDAC6 Q9UBN7 3/20 0.51
HDAC3 O15379 2/20 0.51
HDAC10 Q969S8 2/20 0.51
HDAC8 Q9BY41 2/20 0.51
IL17A Q16552 1/20 0.51
HDAC4 P56524 1/20 0.51
HDAC7 Q8WUI4 1/20 0.51
HDAC11 Q96DB2 1/20 0.51
HDAC9 Q9UKV0 1/20 0.51
HDAC5 Q9UQL6 1/20 0.51
PARP1 P09874 1/20 0.49
CDKN1A P38936 3/20 0.39
BRD2 P25440 1/20 0.38
MIF P14174 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL147081 0.91 BRD4 (0.50) BRD4HDAC1HDAC2HDAC6HDAC3
SCHEMBL378025 0.91 BRD4 (0.50) BRD4HDAC1HDAC2HDAC6HDAC3
SCHEMBL121574 0.87 BRD4 (0.51) BRD4HDAC1HDAC2HDAC6HDAC3
SCHEMBL30435329 0.87 BRD4 (0.51) BRD4HDAC1HDAC2HDAC6HDAC3
SCHEMBL22635789 0.86 BRD4 (0.45) BRD4HDAC1HDAC2HDAC6HDAC3
SCHEMBL378119 0.85 BRD4 (0.71) BRD4HDAC1HDAC2HDAC6HDAC3
SCHEMBL122789 0.85 BRD4 (0.50) BRD4HDAC1HDAC2HDAC6HDAC3
SCHEMBL30434593 0.85 BRD4 (0.50) BRD4HDAC1HDAC2HDAC6HDAC3
SCHEMBL147189 0.84 BRD4 (0.48) BRD4HDAC1HDAC2HDAC6HDAC3
SCHEMBL30434145 0.83 BRD4 (0.50) BRD4HDAC1HDAC2HDAC6HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3268007-B1 COMPOSITIONS AND THERAPEUTIC METHODS FOR THE TREATMENT OF COMPLEMENT-ASSOCIATED DISEASES RESVERLOGIX CORP (CA) 2022-11-09 EP claimed
CN-114984016-A Compositions and methods for treating complement-associated diseases 雷斯韦洛吉克斯公司 2022-09-02 CN claimed
US-20190091235-A1 COMPOSITIONS AND THERAPEUTIC METHODS FOR THE TREATMENT OF COMPLEMENT-ASSOCIATED DISEASES HEPALINK (HONG KONG) LIMITED (HK) 2019-03-28 US claimed
US-10111885-B2 Compositions and therapeutic methods for the treatment of complement-associated diseases RESVERLOGIX CORP. (CA) 2018-10-30 US claimed
EP-2421533-B1 NOVEL ANTI-INFLAMMATORY AGENTS RESVERLOGIX CORP (CA) 2018-10-17 EP claimed
US-20180104245-A1 COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES HEPALINK (HONG KONG) LIMITED (HK) 2018-04-19 US claimed
EP-3268007-A1 COMPOSITIONS AND THERAPEUTIC METHODS FOR THE TREATMENT OF COMPLEMENT-ASSOCIATED DISEASES Resverlogix Corp. (CA) 2018-01-17 EP claimed
US-9757368-B2 Anti-inflammatory agents RESVERLOGIX CORP. (CA) 2017-09-12 US claimed
US-20160346291-A1 COMPOSITIONS AND THERAPEUTIC METHODS FOR ACCELERATED PLAQUE REGRESSION RESVERLOGIX CORP (CA) 2016-12-01 US claimed
WO-2016147053-A1 COMPOSITIONS AND THERAPEUTIC METHODS FOR THE TREATMENT OF COMPLEMENT-ASSOCIATED DISEASES RESVERLOGIX CORP. (CA) 2016-09-22 WO claimed
US-20130281397-A1 TREATMENT OF DISEASES BY EPIGENETIC REGULATION RVX THERAPEUTICS INC. (CA) 2013-10-24 US claimed
US-20120059002-A1 NOVEL ANTI-INFLAMMATORY AGENTS HEPALINK (HONG KONG) LIMITED (HK) 2012-03-08 US claimed
EP-2421533-A1 NOVEL ANTI-INFLAMMATORY AGENTS RESVERLOGIX CORP. (CA) 2012-02-29 EP claimed
US-20120015905-A1 COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES RESVERLOGIX CORP. 2012-01-19 US claimed
US-8053440-B2 Compounds for the prevention and treatment of cardiovascular diseases Resverlogix Corporation (CA) 2011-11-08 US claimed
WO-2010123975-A1 NOVEL ANTI-INFLAMMATORY AGENTS RESVERLOGIX CORP. (CA) 2010-10-28 WO claimed
US-20100004448-A1 METHODS OF PREPARING QUINAZOLINONE DERIVATIVES RESVERLOGIX CORP. (CA) 2010-01-07 US claimed
EP-2118074-A1 COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES RESVERLOGIX CORP. (CA) 2009-11-18 EP claimed
WO-2008092231-A1 COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES RESVERLOGIX CORP. (CA) 2008-08-07 WO claimed
US-20080188467-A1 To regulate the expression of apolipoprotein A-I; atherosclerosis; improved pharmacological properties; 3-(4-hydroxy-3,5-dimethylphenyl)-6,8-dimethoxyisoquinolin-1(2H)-one; to reduce cholesterol levels; agonists HEPALINK (HONG KONG) LIMITED (HK) 2008-08-07 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180104245-A1 COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES APOB, HDLBP, FABP3 BRD4 1910/4885HDAC1 510/4885HDAC2 920/4885
US-10111885-B2 Compositions and therapeutic methods for the treatment of complement-associated diseases C5, CFH, C1QBP BRD4 3811/4885HDAC1 2013/4885HDAC2 1281/4885
US-20130281397-A1 TREATMENT OF DISEASES BY EPIGENETIC REGULATION BRD4, BMI1, BRPF3 BRD4 1/4885HDAC1 41/4885HDAC2 138/4885
US-20160346291-A1 COMPOSITIONS AND THERAPEUTIC METHODS FOR ACCELERATED PLAQUE REGRESSION PCSK9, TGFB1, HMGCR BRD4 3081/4885HDAC1 184/4885HDAC2 515/4885
US-20120059002-A1 NOVEL ANTI-INFLAMMATORY AGENTS VCAM1, ICAM1, IL6 BRD4 192/4885HDAC1 639/4885HDAC2 1208/4885
US-20120015905-A1 COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES APOB, HDLBP, FABP3 BRD4 1910/4885HDAC1 510/4885HDAC2 920/4885
US-20100004448-A1 METHODS OF PREPARING QUINAZOLINONE DERIVATIVES APOB, APOL1, LDLR BRD4 1306/4885HDAC1 1369/4885HDAC2 1714/4885
US-20190091235-A1 COMPOSITIONS AND THERAPEUTIC METHODS FOR THE TREATMENT OF COMPLEMENT-ASSOCIATED DISEASES C5, CFH, C1QBP BRD4 3811/4885HDAC1 2013/4885HDAC2 1281/4885
US-20080188467-A1 To regulate the expression of apolipoprotein A-I; atherosclerosis; improved pharmacological properties; 3-(4-hydroxy-3,5-dimethylphenyl)-6,8-dimethoxyisoquinolin-1(2H)-one; to reduce cholesterol levels; agonists APOB, LDLR, APOL1 BRD4 693/4885HDAC1 1272/4885HDAC2 1753/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.