Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12997994 | 0.82 | RAB9A (0.57) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL11269746 | 0.79 | HPGDS (0.61) | HPGDSSMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL13054047 | 0.79 | RAB9A (0.57) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL1969117 | 0.77 | HPGDS (0.59) | HPGDSSMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL13901726 | 0.77 | ALDH1A1 (0.57) | SMN1; SMN2NPC1RAB9AGAATSHR | |
| SCHEMBL3263722 | 0.76 | HPGDS (0.57) | HPGDSSMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL14747500 | 0.75 | ALDH1A1 (0.52) | SMN1; SMN2NPC1RAB9AGAATSHR | |
| SCHEMBL17279852 | 0.75 | HPGDS (0.60) | HPGDSSMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL10924593 | 0.75 | HPGDS (0.56) | HPGDSSMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL8287820 | 0.74 | BCHE (0.54) | SMN1; SMN2NPC1RAB9AGAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130123265-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2013-05-16 | — | — | US | disclosed |
| US-8389567-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2013-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130123265-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, ATP2A1 | HPGDS 395/4885SMN1; SMN2 732/4885NPC1 211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.