SCHEMBL147478

SCHEMBL147478

FC(F)(F)c1cc(Cl)[c]c(Cl)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.40
TSHR P16473 3/20 0.40
CYP3A4 P08684 1/20 0.40
HPGD P15428 1/20 0.40
ALOX15 P16050 1/20 0.40
HIF1A Q16665 1/20 0.40
TXNRD1 Q16881 1/20 0.40
TXNRD3 Q86VQ6 1/20 0.40
TXNRD2 Q9NNW7 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
CES2 O00748 1/20 0.37
GPR35 Q9HC97 2/20 0.35
AHR P35869 1/20 0.34
IDO1 P14902 2/20 0.33
NOS3 P29474 1/20 0.33
NOS2 P35228 1/20 0.33
RAPGEF4 Q8WZA2 1/20 0.32
PDE2A O00408 1/20 0.32
MAPK1 P28482 1/20 0.31
KDM4E B2RXH2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1531107 0.85 ALDH1A1 (0.35) ALDH1A1TSHRCYP3A4HPGDALOX15
SCHEMBL697742 0.85 ALDH1A1 (0.35) ALDH1A1TSHRCYP3A4HPGDALOX15
SCHEMBL698918 0.84 RAPGEF4 (0.35) ALDH1A1TSHRCYP3A4HPGDALOX15
SCHEMBL147500 0.84 ALDH1A1 (0.34) ALDH1A1TSHRCYP3A4HPGDALOX15
SCHEMBL289621 0.79
SCHEMBL697656 0.79
SCHEMBL6055718 0.79 KIF11 (0.33) ALDH1A1TSHRCYP3A4HPGDALOX15
SCHEMBL7821427 0.79 GABRP (0.36) ALDH1A1TSHRCYP3A4HPGDALOX15
SCHEMBL1531196 0.76 CYP3A4 (0.53) ALDH1A1TSHRCYP3A4HPGDALOX15
SCHEMBL1842896 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 864 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109134376-B Synthetic method of 3-trifluoroacetyl indazole derivative 华南理工大学 2021-09-21 CN claimed
EP-3416959-B1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2021-05-12 EP claimed
EP-3497101-B1 SUBSTITUTED 2-HETEROCYCLYL IMIDAZOLYL-CARBOXAMIDES AS PESTICIDES BAYER CROPSCIENCE AG (DE) 2020-12-30 EP claimed
US-10660333-B2 Substituted 2-heterocyclylimidazolylcarboxamides as pesticides BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2020-05-26 US claimed
EP-3497101-A1 SUBSTITUTED 2-HETEROCYCLYL IMIDAZOLYL-CARBOXAMIDES AS PEST CONTROL AGENTS Bayer CropScience Aktiengesellschaft (DE) 2019-06-19 EP claimed
US-20190166837-A1 SUBSTITUTED 2-HETEROCYCLYLIMIDAZOLYLCARBOXAMIDES AS PESTICIDES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2019-06-06 US claimed
CN-109843878-A Substituted 2-heterocyclyl imidazolylcarboxamides as pest control agents 拜耳作物科学股份公司 2019-06-04 CN claimed
US-10299478-B2 Pyrazolyltriazolylpyridines as pesticides BAYER ANIMAL HEALTH GMBH (DE) 2019-05-28 US claimed
EP-3157913-B1 PYRAZOLYL TRIAZOLYL PYRIDINES AS PESTICIDE BAYER ANIMAL HEALTH GMBH (DE) 2019-04-17 EP claimed
EP-3412659-A1 PROCESSES FOR THE MANUFACTURE OF SULFUR-SUBSTITUTED PYRAZOLE DERIVATIVES SOLVAY SA (BE) 2018-12-12 EP claimed
CN-1039345-A TRIAZOLE INSECTICIDES SCHERING AGROCHEMICALS LTD (GB) 1990-02-07 CN claimed
EP-0352944-A1 Derivatives of N-phenylpyrazoles RHONE-POULENC AGRICULTURE LIMITED (GB) 1990-01-31 EP claimed
EP-0350237-A2 Triazole insecticides SCHERING AGROCHEMICALS LIMITED (GB) 1990-01-10 EP claimed
US-4810283-A PRE- AND POSTEMERGENCE BAYER AKTIENGESELLSCHAFT (DE) 1989-03-07 US claimed
CN-1030577-A Disinsection method with 2-phenylimidazole derivative MAY & BAKER CO LTD (GB) 1989-01-25 CN claimed
CN-88103601-A N-PHENYLPYRAZOLE DERIVATIVES 1988-12-28 CN claimed
EP-0295117-A1 Derivatives of N-phenylpyrazoles RHONE-POULENC AGRICULTURE LIMITED (GB) 1988-12-14 EP claimed
US-4774254-A INSECTICIDES, MITICIDES BAYER AKTIENGESELLSCHAFT (DE) 1988-09-27 US claimed
EP-0243636-A1 1-Aryl-4-trifluoromethyl-5-amino pyrazoles as pesticides BAYER AG (DE) 1987-11-04 EP claimed
US-4629495-A Herbicidal 5-amino-4-cyano-1-phenylpyrazoles MAY & BAKER LIMITED (GB) 1986-12-16 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10299478-B2 Pyrazolyltriazolylpyridines as pesticides PRDX4, PRDX1, ATL3 ALDH1A1 1058/4885TSHR 631/4885CYP3A4 94/4885
US-20190166837-A1 SUBSTITUTED 2-HETEROCYCLYLIMIDAZOLYLCARBOXAMIDES AS PESTICIDES DDT, PTMS, TSNAX ALDH1A1 3634/4885TSHR 639/4885CYP3A4 352/4885
US-10660333-B2 Substituted 2-heterocyclylimidazolylcarboxamides as pesticides DDT, PTMS, TSNAX ALDH1A1 3634/4885TSHR 639/4885CYP3A4 352/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.