Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL85313 | 0.81 | KCNH2 (0.46) | KCNH2HRH3STSTBXAS1CHRNB2 | |
| SCHEMBL14592630 | 0.74 | EPHX2 (0.46) | KCNH2HRH3STSKMT2ALMNA | |
| SCHEMBL14592611 | 0.71 | KCNJ1 (0.52) | KCNH2CHRNB2CHRNA4KMT2ACYP1A2 | |
| SCHEMBL14592072 | 0.71 | MAPT (0.52) | CHRNB2CHRNA5CHRNA7CHRNA4KMT2A | |
| SCHEMBL9384519 | 0.70 | HRH3 (0.47) | KCNH2HRH3TBXAS1CHRNB2CHRNA5 | |
| SCHEMBL13437495 | 0.69 | TDP1 (0.41) | KCNH2HRH3KMT2ATDP1L3MBTL1 | |
| SCHEMBL8536518 | 0.69 | ALDH1A1 (0.51) | KCNH2HRH3STSKMT2ALMNA | |
| SCHEMBL9387166 | 0.68 | LMNA (0.55) | KCNH2HRH3CHRNB2CHRNA5CHRNA7 | |
| SCHEMBL27574704 | 0.68 | CYP2C9 (0.54) | KCNH2HRH3TBXAS1KMT2AMAOA | |
| SCHEMBL85754 | 0.68 | KCNH2 (0.44) | KCNH2HRH3STSTBXAS1CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130065882-A1 | VLA-4 inhibitory drug | MACHINAGA NOBUO (JP) | 2013-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130065882-A1 | VLA-4 inhibitory drug | VCAM1, ITGB4, ITGA4 | KCNH2 503/4885HRH3 372/4885STS 2041/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.