Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 1.00 |
| ▸ | RAB9A | P51151 | 7/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.75 |
| ▸ | TP53 | P04637 | 2/20 | 0.75 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.75 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.66 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL643747 | 0.86 | NPC1 (1.00) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9431221 | 0.83 | NPC1 (0.76) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9431284 | 0.81 | NPC1 (0.76) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9816345 | 0.81 | NPC1 (1.00) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL5897862 | 0.80 | NPC1 (0.71) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL17817588 | 0.80 | SPHK2 (1.00) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL27846960 | 0.79 | NPC1 (0.69) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL11033427 | 0.79 | RAB9A (0.82) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8540574 | 0.78 | CYP3A4 (0.69) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL17329343 | 0.78 | NPC1 (0.67) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9101600-B2 | Compounds as RORγt modulators and uses thereof | NEW YORK UNIVERSITY (US) | 2015-08-11 | — | — | US | disclosed |
| US-9101600-B2 | Compounds as RORγt modulators and uses thereof | NEW YORK UNIVERSITY (US) | 2015-08-11 | — | — | US | disclosed |
| US-20130065842-A1 | COMPOUNDS AS RORyT MODULATORS AND USES THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2013-03-14 | — | — | US | disclosed |
| US-20130065842-A1 | COMPOUNDS AS RORyT MODULATORS AND USES THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2013-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130065842-A1 | COMPOUNDS AS RORyT MODULATORS AND USES THEREOF | RORC, RORB, RORA | NPC1 1496/4885RAB9A 2380/4885MAPT 3323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.