Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 1.00 |
| ▸ | RAB9A | P51151 | 6/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 0.81 |
| ▸ | MEN1 | O00255 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14769346 | 0.86 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL16756346 | 0.83 | NPC1 (0.73) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL8540574 | 0.81 | CYP3A4 (0.69) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL6532397 | 0.80 | NPC1 (0.65) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL7933620 | 0.80 | ALDH1A1 (0.71) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL11700474 | 0.79 | RAB9A (0.65) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL11584604 | 0.79 | ALDH1A1 (1.00) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL5492363 | 0.79 | RAB9A (0.65) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL11167021 | 0.79 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL29500234 | 0.79 | ALDH1A1 (0.69) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119675-B2 | Benzimidazole derivatives | MERCK PATENT GMBH (DE) | 2012-02-21 | — | — | US | disclosed |
| US-20100016372-A1 | Benzimidazole Derivatives | MERCK PATENT GMBH (DE) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016372-A1 | Benzimidazole Derivatives | GPR119, GLP1R, H1-3 | NPC1 2647/4885RAB9A 484/4885SMN1; SMN2 3190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.