Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDF2 | Q9Y5A9 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9414195 | 0.72 | YTHDF2 (0.83) | YTHDF2DAOGAAADORA3ADORA2B | |
| SCHEMBL126983 | 0.70 | KMT2A (0.44) | GAAADORA3ADORA2BHSD17B10ALDH1A1 | |
| SCHEMBL7964576 | 0.70 | KMT2A (0.53) | GAAADORA3ADORA2BRECQLHSD17B10 | |
| SCHEMBL5440251 | 0.70 | CYP3A4 (0.42) | GAAADORA3ADORA2BRECQLHSD17B10 | |
| SCHEMBL9756675 | 0.70 | ALDH1A1 (0.49) | GAAADORA3ADORA2BRECQLHSD17B10 | |
| SCHEMBL26948701 | 0.67 | ALOX15 (0.40) | GAAADORA3ADORA2BPOLBALOX15 | |
| SCHEMBL9414250 | 0.66 | GAA (0.39) | GAAADORA3ADORA2BHSD17B10ALDH1A1 | |
| SCHEMBL157928 | 0.64 | CYP3A4 (0.71) | GAAADORA3ADORA2BRECQLNPC1 | |
| SCHEMBL3885015 | 0.64 | CYP3A4 (0.54) | GAAADORA3ADORA2BRECQLHSD17B10 | |
| SCHEMBL27768491 | 0.64 | YTHDF2 (0.58) | YTHDF2DAOADORA2BPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9321736-B2 | Pyrimidine cyclohexyl glucocorticoid receptor modulators | CORCEPT THERAPEUTICS, INC. (US) | 2016-04-26 | — | — | US | disclosed |
| EP-2685827-B1 | PYRIMIDINE CYCLOHEXYL GLUCOCORTICOID RECEPTOR MODULATORS | CORCEPT THERAPEUTICS INC (US) | 2016-02-03 | — | — | EP | disclosed |
| US-20150065532-A1 | PYRIMIDINE CYCLOHEXYL GLUCOCORTICOID RECEPTOR MODULATORS | CORCEPT THERAPEUTICS, INC. | 2015-03-05 | — | — | US | disclosed |
| US-8906917-B2 | Pyrimidine cyclohexyl glucocorticoid receptor modulators | CORCEPT THERAPEUTICS, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-20140162361-A1 | PYRIMIDINE CYCLOHEXYL GLUCOCORTICOID RECEPTOR MODULATORS | CORCEPT THERAPEUTICS, INC. | 2014-06-12 | — | — | US | disclosed |
| US-20130072486-A1 | PYRIMIDINE CYCLOHEXYL GLUCOCORTICOID RECEPTOR MODULATORS | CORCEPT THERAPEUTICS, INC. (US) | 2013-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140162361-A1 | PYRIMIDINE CYCLOHEXYL GLUCOCORTICOID RECEPTOR MODULATORS | NR3C1, NR3C2, MC2R | YTHDF2 2619/4885DAO 4222/4885GAA 4605/4885 |
| US-20130072486-A1 | PYRIMIDINE CYCLOHEXYL GLUCOCORTICOID RECEPTOR MODULATORS | NR3C1, NR3C2, MC2R | YTHDF2 2619/4885DAO 4222/4885GAA 4605/4885 |
| US-20150065532-A1 | PYRIMIDINE CYCLOHEXYL GLUCOCORTICOID RECEPTOR MODULATORS | NR3C1, NR3C2, MC2R | YTHDF2 2619/4885DAO 4222/4885GAA 4605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.