Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.46 |
| ▸ | CXCL8 | P10145 | 5/20 | 0.45 |
| ▸ | CFD | P00746 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.42 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | ALB | P02768 | 1/20 | 0.42 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.42 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.42 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8991903 | 0.85 | ALDH1A1 (0.44) | AKR1B1TDP1PTGS2NR4A2CYP2D6 | |
| Iodide SCHEMBL31305035 | 0.83 | AKR1B1 (0.73) | AKR1B1TDP1BCAT2CXCL8PTGS2 | |
| SCHEMBL30359 | 0.81 | AKR1B1 (0.76) | AKR1B1TDP1BCAT2CXCL8PTGS2 | |
| SCHEMBL29410826 | 0.81 | AKR1B1 (0.76) | AKR1B1TDP1BCAT2CXCL8PTGS2 | |
| SCHEMBL2875329 | 0.81 | TSHR (0.67) | AKR1B1CYP2D6TSHRHIF1AKDM4E | |
| SCHEMBL6366958 | 0.79 | TSHR (0.64) | AKR1B1CYP2D6TSHRHIF1AKDM4E | |
| SCHEMBL5971823 | 0.79 | NR4A2 (0.41) | AKR1B1TDP1NR4A2CYP2D6TSHR | |
| SCHEMBL7301923 | 0.79 | HIF1A (0.51) | BCAT2NR4A2TSHRHIF1AKDM4E | |
| SCHEMBL16702802 | 0.79 | KMT2A (0.53) | CXCL8KDM4ESMN1; SMN2 | |
| SCHEMBL8991883 | 0.79 | ALDH1A1 (0.57) | AKR1B1KDM4EMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9199927-B2 | Guanidinobenzoic acid compound | ASTELLAS PHARMA INC. (JP) | 2015-12-01 | — | — | US | disclosed |
| US-20140378459-A1 | GUANIDINOBENZOIC ACID COMPOUND | ASTELLAS PHARMA INC. (JP) | 2014-12-25 | — | — | US | disclosed |
| WO-2013039187-A1 | GUANIDINOBENZOIC ACID COMPOUND | アステラス製薬株式会社 (JP) | 2013-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378459-A1 | GUANIDINOBENZOIC ACID COMPOUND | SERPINB1, REN, SPINT2 | AKR1B1 1375/4885TDP1 1341/4885BCAT2 295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.