SCHEMBL1481069

SCHEMBL1481069

CC(C)(C)c1cc2c(cc1-c1ccc(-c3ccccc3)cc1)C(=O)c1cc(-c3ccc(-c4ccccc4)cc3)c(C(C)(C)C)cc1-2

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.44
RAB9A P51151 3/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
LMNA P02545 2/20 0.44
ATM Q13315 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
MEN1 O00255 1/20 0.44
APAF1 O14727 1/20 0.44
MAPT P10636 1/20 0.44
THRB P10828 1/20 0.44
XBP1 P17861 1/20 0.44
PTBP1 P26599 1/20 0.44
HTT P42858 1/20 0.44
GALK1 P51570 1/20 0.44
BLM P54132 1/20 0.44
SMAD3 P84022 1/20 0.44
KMT2A Q03164 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
CASP3 P42574 2/20 0.43
SENP8 Q96LD8 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1479830 0.90 NPC1 (0.62) NPC1RAB9AL3MBTL1LMNAATM
SCHEMBL1482754 0.83 PTGS2 (0.40) NPC1RAB9AL3MBTL1SMN1; SMN2MEN1
SCHEMBL1482792 0.80 APP (0.42) NPC1RAB9AL3MBTL1MAPTCASP3
SCHEMBL1480675 0.80 OPRD1 (0.42) NPC1RAB9AL3MBTL1SMN1; SMN2MAPT
SCHEMBL27727222 0.78 PTGS1 (0.36) L3MBTL1SMN1; SMN2MEN1MAPTKMT2A
SCHEMBL16411281 0.77 MEN1 (0.37) ATMMEN1MAPTKMT2AALDH1A1
SCHEMBL1479792 0.76 NPC1 (0.47) NPC1RAB9AL3MBTL1LMNAATM
SCHEMBL1480432 0.76 TDP2 (0.38) MAPTESR1ESR2RXRARXRB
SCHEMBL668815 0.76 MEN1 (0.42) NPC1RAB9AL3MBTL1LMNAATM
SCHEMBL4567546 0.75 RAB9A (0.64) NPC1RAB9AL3MBTL1LMNAATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8293856-B2 Process for preparing olefin polymer using mixed catalyst MITSUI CHEMICALS, INC. (JP) 2012-10-23 US disclosed
US-20110077369-A1 PROCESS FOR PREPARING OLEFIN POLYMER USING MIXED CATALYST MITSU CHEMICALS, INC. 2011-03-31 US disclosed