SCHEMBL14818488

SCHEMBL14818488

NC(CP(=O)(O)O)C(N)c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
SRC P12931 1/20 0.50
DPP4 P27487 2/20 0.48
ANPEP P15144 4/20 0.47
LAP3 P28838 3/20 0.47
ACP3 P15309 4/20 0.46
ERAP1 Q9NZ08 2/20 0.44
ERAP2 Q6P179 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14818493 0.83 SRC (0.48) SRCDPP4ANPEPLAP3ACP3
SCHEMBL11286460 0.80 SRC (0.54) SRCANPEPLAP3ACP3ERAP1
SCHEMBL875769 0.77 SRC (0.60) SRCANPEPLAP3ACP3
SCHEMBL14818500 0.76 LAP3 (0.65) ANPEPLAP3ACP3ERAP1ERAP2
SCHEMBL14831728 0.74 SRC (0.52) SRCDPP4ANPEPLAP3ACP3
SCHEMBL11061163 0.74 SRC (0.56) SRCACP3
SCHEMBL4454292 0.74 ACP3 (0.66) SRCACP3
SCHEMBL8729175 0.73 SRC (0.50) SRCDPP4ANPEPLAP3ACP3
SCHEMBL8729170 0.73 SRC (0.50) SRCDPP4ANPEPLAP3ACP3
SCHEMBL499206 0.73 SRC (0.46) SRCANPEPLAP3ACP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9492466-B2 Beta-hydroxy-gamma-aminophosphonates for treating immune disorders NUCITEC S.A. DE C.V. (MX) 2016-11-15 US disclosed
US-20140107079-A1 Beta-hydroxy-gamma-aminophosphonates for Treating Immune Disorders Nucites S.A. de C.V. (MX) 2014-04-17 US disclosed
US-8536362-B2 β-hydroxy-γ-aminophosphonates and methods for the preparation and use thereof NUCITEC S.A. DE C.V. (MX) 2013-09-17 US disclosed
US-20130079308-A1 Beta-Hydroxy-Gamma-Aminophosphonates and Methods for the Preparation and Use Thereof NUCITEC S.A. DE C.V. (MX) 2013-03-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140107079-A1 Beta-hydroxy-gamma-aminophosphonates for Treating Immune Disorders IFNG, HPGDS, AASDHPPT SRC 2945/4885DPP4 2000/4885ANPEP 295/4885
US-20130079308-A1 Beta-Hydroxy-Gamma-Aminophosphonates and Methods for the Preparation and Use Thereof CPT1A, ACAT1, ABAT SRC 4175/4885DPP4 539/4885ANPEP 322/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.