Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.59 |
| ▸ | TYK2 | P29597 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13162412 | 0.88 | SMN1; SMN2 (0.82) | SMN1; SMN2ALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL13161957 | 0.85 | MAPK1 (1.00) | MAPK1SMN1; SMN2ALDH1A1HPGDPOLB | |
| SCHEMBL13161962 | 0.85 | SMN1; SMN2 (0.60) | MAPK1SMN1; SMN2ALDH1A1HPGDRAB9A | |
| SCHEMBL14803881 | 0.82 | SMN1; SMN2 (0.65) | MAPK1SMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL11707705 | 0.80 | HPGD (0.62) | SMN1; SMN2ALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL15400956 | 0.79 | SMN1; SMN2 (0.53) | MAPK1SMN1; SMN2ALDH1A1HPGDPOLB | |
| SCHEMBL4354272 | 0.78 | RAB9A (0.88) | SMN1; SMN2ALDH1A1RAB9ANPC1KMT2A | |
| SCHEMBL11812817 | 0.78 | KMT2A (0.63) | SMN1; SMN2ALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL28574459 | 0.78 | ALDH1A1 (0.73) | SMN1; SMN2ALDH1A1HPGDPOLBKMT2A | |
| SCHEMBL2228229 | 0.78 | HPGD (0.67) | SMN1; SMN2ALDH1A1HPGDRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9169246-B2 | Pyrazoloquinolinone derivatives, preparation thereof and therapeutic use thereof | SANOFI (FR) | 2015-10-27 | — | — | US | disclosed |
| US-20140235616-A1 | PYRAZOLOQUINOLINONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2014-08-21 | — | — | US | disclosed |
| US-20130079337-A1 | PYRAZOLOQUINOLINONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2013-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130079337-A1 | PYRAZOLOQUINOLINONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | CYP11B2, COQ8A, CYP1A2 | MAPK1 1939/4885SMN1; SMN2 1132/4885ALDH1A1 88/4885 |
| US-20140235616-A1 | PYRAZOLOQUINOLINONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | CYP11B2, CYP1A2, COQ8A | MAPK1 1758/4885SMN1; SMN2 1192/4885ALDH1A1 97/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.