Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL204814 | 0.76 | LMNA (0.48) | ALDH1A1LMNAHPGDMAPTSTAT3 | |
| SCHEMBL14829944 | 0.73 | VCP (0.42) | ALDH1A1LMNAMAPTSTAT3NOD2 | |
| SCHEMBL17404758 | 0.72 | THRA (0.40) | ALDH1A1THRATHRBHPGDMAPT | |
| SCHEMBL7649071 | 0.72 | LMNA (0.45) | ALDH1A1LMNAHPGDMAPTSTAT3 | |
| SCHEMBL30786779 | 0.72 | ALDH1A1 (0.50) | ALDH1A1LMNAHPGDMAPTSTAT3 | |
| SCHEMBL6071880 | 0.71 | LMNA (0.57) | ALDH1A1LMNATHRATHRBMAPT | |
| SCHEMBL9260093 | 0.71 | THRA (0.50) | ALDH1A1LMNATHRATHRBMAPT | |
| SCHEMBL11902545 | 0.69 | CES2 (0.40) | THRATHRB | |
| SCHEMBL28487605 | 0.69 | MEN1 (0.49) | ALDH1A1HPGDMAPTKMT2AMEN1 | |
| SCHEMBL11504188 | 0.69 | ALDH1A1 (0.48) | ALDH1A1LMNAHPGDMAPTSTAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10766872-B2 | Compounds for the treatment of mycobacterial infections | THE BOARD INSTITUTE, INC. (US) | 2020-09-08 | — | — | US | disclosed |
| US-10766872-B2 | Compounds for the treatment of mycobacterial infections | THE BOARD INSTITUTE, INC. (US) | 2020-09-08 | — | — | US | disclosed |
| US-RE48105-E1 | Compounds for the treatment of mycobacterial infections | THE BROAD INSTITUTE, INC. (US) | 2020-07-21 | — | — | US | disclosed |
| US-RE48105-E1 | Compounds for the treatment of mycobacterial infections | THE BROAD INSTITUTE, INC. (US) | 2020-07-21 | — | — | US | disclosed |
| US-20170327481-A1 | COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | BROAD INST INC (US) | 2017-11-16 | — | — | US | disclosed |
| US-20170327481-A1 | COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | BROAD INST INC (US) | 2017-11-16 | — | — | US | disclosed |
| US-20170327481-A1 | COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | BROAD INST INC (US) | 2017-11-16 | — | — | US | disclosed |
| US-9682064-B2 | Compounds for the treatment of mycobacterial infections | THE BROAD INSTITUTE, INC. (US) | 2017-06-20 | — | — | US | disclosed |
| US-9682064-B2 | Compounds for the treatment of mycobacterial infections | THE BROAD INSTITUTE, INC. (US) | 2017-06-20 | — | — | US | disclosed |
| US-9682064-B2 | Compounds for the treatment of mycobacterial infections | THE BROAD INSTITUTE, INC. (US) | 2017-06-20 | — | — | US | disclosed |
| US-20170014378-A1 | COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | BROAD INST INC (US) | 2017-01-19 | — | — | US | disclosed |
| US-20170014378-A1 | COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | BROAD INST INC (US) | 2017-01-19 | — | — | US | disclosed |
| US-20170014378-A1 | COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | BROAD INST INC (US) | 2017-01-19 | — | — | US | disclosed |
| US-9416121-B2 | Compounds for the treatment of mycobacterial infections | THE BROAD INSTITUTE, INC. (US) | 2016-08-16 | — | — | US | disclosed |
| US-9416121-B2 | Compounds for the treatment of mycobacterial infections | THE BROAD INSTITUTE, INC. (US) | 2016-08-16 | — | — | US | disclosed |
| US-9416121-B2 | Compounds for the treatment of mycobacterial infections | THE BROAD INSTITUTE, INC. (US) | 2016-08-16 | — | — | US | disclosed |
| US-20140296232-A1 | COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | MASSACHUSETTS GENERAL HOSPITAL (US) | 2014-10-02 | — | — | US | disclosed |
| US-20140296232-A1 | COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | MASSACHUSETTS GENERAL HOSPITAL (US) | 2014-10-02 | — | — | US | disclosed |
| US-20140296232-A1 | COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | MASSACHUSETTS GENERAL HOSPITAL (US) | 2014-10-02 | — | — | US | disclosed |
| WO-2013049567-A1 | COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | THE BROAD INSTITUTE, INC. (US) | 2013-04-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170327481-A1 | COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | GBA1, ASAH2, MPI | ALDH1A1 759/4885LMNA 3074/4885THRA 3220/4885 |
| US-20170014378-A1 | COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | GBA1, ASAH2, MPI | ALDH1A1 759/4885LMNA 3074/4885THRA 3220/4885 |
| US-20140296232-A1 | COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | GBA1, ASAH2, MPI | ALDH1A1 759/4885LMNA 3074/4885THRA 3220/4885 |
| US-10766872-B2 | Compounds for the treatment of mycobacterial infections | GBA1, ASAH2, MPI | ALDH1A1 759/4885LMNA 3074/4885THRA 3220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.