Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14831388 | 0.79 | RAB9A (0.45) | RAB9AALDH1A1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL14830095 | 0.79 | MT-CO2 (0.44) | RAB9ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL3650581 | 0.77 | ALDH1A1 (0.43) | RAB9AALDH1A1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL3661310 | 0.73 | KEAP1 (0.49) | RAB9AALDH1A1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL6266590 | 0.72 | SMN1; SMN2 (0.49) | RAB9AALDH1A1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL3656769 | 0.71 | TSHR (0.51) | RAB9AALDH1A1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL29001248 | 0.71 | NPC1 (0.52) | RAB9AALDH1A1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL6717574 | 0.71 | TSHR (0.49) | RAB9AALDH1A1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL8773038 | 0.70 | ALDH1A1 (0.50) | RAB9AALDH1A1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL11866005 | 0.69 | ALDH1A1 (0.43) | RAB9AALDH1A1SMN1; SMN2KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2760845-A1 | HETEROCYCLIC COMPOUNDS AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER | Amgen Inc. (US) | 2014-08-06 | — | — | EP | disclosed |
| WO-2013049250-A1 | HETEROCYCLIC COMPOUNDS AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2013-04-04 | — | — | WO | disclosed |