SCHEMBL1483113

SCHEMBL1483113

C=CCC1NC(=O)C(CC=C)NC1=O

nearest known ligand 0.52

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.52
MAPT P10636 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
GAA P10253 1/20 0.30
HPGD P15428 1/20 0.30
MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2143425 0.81 ALDH1A1 (0.50) ALDH1A1MAPTMEN1KMT2AGAA
SCHEMBL1598193 0.80 ALDH1A1 (0.64) ALDH1A1MAPTL3MBTL1MEN1KMT2A
Formaldehyde SCHEMBL8154204 0.80 ALDH1A1 (0.48) ALDH1A1MAPTMEN1KMT2AGAA
SCHEMBL3290270 0.77 ALDH1A1 (0.41) ALDH1A1MAPTL3MBTL1MEN1KMT2A
SCHEMBL11095724 0.75
SCHEMBL24162936 0.75 ALDH1A1 (0.40) ALDH1A1GAAHPGDMAPK1
SCHEMBL5800419 0.72 KDM4E (0.53) ALDH1A1MAPTMEN1KMT2AGAA
SCHEMBL9886463 0.70 ALDH1A1 (0.39) ALDH1A1
SCHEMBL1728513 0.70 ALDH1A1 (0.39) ALDH1A1
SCHEMBL17254460 0.70 ALDH1A1 (0.30) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1687281-A1 SYNTHESIS OF 2-CHLORO-3,6-DIALKYL PYRAZINES Pharmacia & Upjohn Company LLC (US) 2006-08-09 EP claimed
WO-2005049583-A1 SYNTHESIS OF 2-CHLORO-3,6-DIALKYL PYRAZINES PHARMACIA & UPJOHN COMPANY LLC (US) 2005-06-02 WO claimed
US-20050107610-A1 Synthesis of 2-chloro-3,6-dialkyl pyrazines PFIZER INC 2005-05-19 US claimed
US-20230242491-A1 DIMERS FROM BIOREACHABLE MOLECULES AS COPOLYMERS ZYMERGEN INC. (US) 2023-08-03 US disclosed
US-20230242491-A1 DIMERS FROM BIOREACHABLE MOLECULES AS COPOLYMERS ZYMERGEN INC. (US) 2023-08-03 US disclosed
WO-2022006023-A1 DIMERS FROM BIOREACHABLE MOLECULES AS COPOLYMERS ZYMERGEN INC. (US) 2022-01-06 WO disclosed
EP-1773484-B1 FUNCTIONALIZED PARTICLES HUNTSMAN TEXTILE EFFECTS GER (DE) 2015-05-13 EP disclosed
US-8546509-B2 Functionalized particles HUNTSMAN TEXTILE EFFECTS (GERMANY) GMBH (US) 2013-10-01 US disclosed
US-20110077375-A1 Functionalized particles HUNTSMAN TEXTILE EFFECTS (GERMANY) GMBH (DE) 2011-03-31 US disclosed
EP-1773484-A1 FUNCTIONALIZED PARTICLES CIBA SPECIALTY CHEMICALS HOLDING INC. Patent Departement (CH) 2007-04-18 EP disclosed
EP-1687281-A1 SYNTHESIS OF 2-CHLORO-3,6-DIALKYL PYRAZINES Pharmacia & Upjohn Company LLC (US) 2006-08-09 EP disclosed
EP-1687281-A1 SYNTHESIS OF 2-CHLORO-3,6-DIALKYL PYRAZINES Pharmacia & Upjohn Company LLC (US) 2006-08-09 EP disclosed
WO-2006013165-A1 FUNCTIONALIZED PARTICLES CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2006-02-09 WO disclosed
WO-2005049583-A1 SYNTHESIS OF 2-CHLORO-3,6-DIALKYL PYRAZINES PHARMACIA & UPJOHN COMPANY LLC (US) 2005-06-02 WO disclosed
WO-2005049583-A1 SYNTHESIS OF 2-CHLORO-3,6-DIALKYL PYRAZINES PHARMACIA & UPJOHN COMPANY LLC (US) 2005-06-02 WO disclosed
US-20050107610-A1 Synthesis of 2-chloro-3,6-dialkyl pyrazines PFIZER INC 2005-05-19 US disclosed
US-20050107610-A1 Synthesis of 2-chloro-3,6-dialkyl pyrazines PFIZER INC 2005-05-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230242491-A1 DIMERS FROM BIOREACHABLE MOLECULES AS COPOLYMERS HDHD5, HAO2, ALAD ALDH1A1 2236/4885MAPT 2075/4885L3MBTL1 3051/4885
US-20050107610-A1 Synthesis of 2-chloro-3,6-dialkyl pyrazines DCLK2, DCK, PDK2 ALDH1A1 1831/4885MAPT 3943/4885L3MBTL1 3748/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.