SCHEMBL14849461

SCHEMBL14849461

CC(C)(C(=O)Nc1ccccc1)C(=O)Nc1ccccc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDK1 Q15118 2/20 0.63
PDK2 Q15119 2/20 0.63
PDK3 Q15120 2/20 0.63
PDK4 Q16654 2/20 0.63
L3MBTL1 Q9Y468 1/20 0.58
NAPRT Q6XQN6 1/20 0.58
HSD17B10 Q99714 1/20 0.58
TP53 P04637 1/20 0.56
EPHX1 P07099 1/20 0.56
TSHR P16473 1/20 0.56
EPHX2 P34913 1/20 0.56
CDK9 P50750 1/20 0.56
SMN1; SMN2 Q16637 1/20 0.56
CLK4 Q9HAZ1 1/20 0.56
MAPT P10636 4/20 0.55
HPGD P15428 2/20 0.55
KMT2A Q03164 2/20 0.55
MEN1 O00255 1/20 0.55
ALDH1A1 P00352 1/20 0.55
MAPK1 P28482 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13333876 0.90 PDK1 (0.58) PDK1PDK2PDK3PDK4L3MBTL1
SCHEMBL16892943 0.88 PDK1 (0.56) PDK1PDK2PDK3PDK4L3MBTL1
SCHEMBL83110 0.86 L3MBTL1 (0.78) PDK1PDK2PDK3PDK4L3MBTL1
SCHEMBL13333851 0.86 PDK1 (0.54) PDK1PDK2PDK3PDK4L3MBTL1
SCHEMBL8442488 0.85 PDK1 (0.53) PDK1PDK2PDK3PDK4L3MBTL1
SCHEMBL27308616 0.85 PDK1 (0.53) PDK1PDK2PDK3PDK4L3MBTL1
SCHEMBL436619 0.84 PDK1 (0.61) PDK1PDK2PDK3PDK4L3MBTL1
SCHEMBL3129785 0.84 PDK1 (0.67) PDK1PDK2PDK3PDK4L3MBTL1
SCHEMBL10974469 0.84 TP53 (0.58) PDK1PDK2PDK3PDK4L3MBTL1
SCHEMBL10989896 0.83 MAPT (0.61) PDK1PDK2PDK3PDK4L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116813659-A Chiral aryl iodine catalyst with threonine as chiral source, and synthetic method and application thereof 浙江工业大学 2023-09-29 CN disclosed
EP-2764053-B1 IRON(II) CONTAINING COMPLEX AND CONDENSATION REACTION CATALYSTS, METHODS FOR PREPARING THE CATALYSTS, AND COMPOSITIONS CONTAINING THE CATALYSTS DOW CORNING (US) 2017-03-15 EP disclosed
US-9328205-B2 Iron(III) containing complex and condensation reaction catalysts, methods for preparing the catalysts, and compositions containing the catalysts DOW CORNING CORPORATION (US) 2016-05-03 US disclosed
US-9328205-B2 Iron(III) containing complex and condensation reaction catalysts, methods for preparing the catalysts, and compositions containing the catalysts DOW CORNING CORPORATION (US) 2016-05-03 US disclosed
US-9156948-B2 Iron(II) containing complex and condensation reaction catalysts, methods for preparing the catalysts, and compositions containing the catalysts DOW CORNING CORPORATION (US) 2015-10-13 US disclosed
US-9156948-B2 Iron(II) containing complex and condensation reaction catalysts, methods for preparing the catalysts, and compositions containing the catalysts DOW CORNING CORPORATION (US) 2015-10-13 US disclosed
US-20140371056-A1 Iron(III) Containing Complex and Condensation Reaction Catalysts, Methods for Preparing the Catalysts, and Compositions Containing the Catalysts DOW COMING CORPORATION (US) 2014-12-18 US disclosed
US-20140371056-A1 Iron(III) Containing Complex and Condensation Reaction Catalysts, Methods for Preparing the Catalysts, and Compositions Containing the Catalysts DOW COMING CORPORATION (US) 2014-12-18 US disclosed
US-20140296467-A1 Iron(II) Containing Complex and Condensation Reaction Catalysts, Methods for Preparing the Catalysts, and Compositions Containing the Catalysts DOW CORNING CORPORATION (US) 2014-10-02 US disclosed
US-20140296467-A1 Iron(II) Containing Complex and Condensation Reaction Catalysts, Methods for Preparing the Catalysts, and Compositions Containing the Catalysts DOW CORNING CORPORATION (US) 2014-10-02 US disclosed
WO-2013052585-A2 IRON(III) CONTAINING COMPLEX AND CONDENSATION REACTION CATALYSTS, METHODS FOR PREPARING THE CATALYSTS, AND COMPOSITIONS CONTAINING THE CATALYSTS DOW CORNING CORPORATION (US) 2013-04-11 WO disclosed
WO-2013052588-A1 IRON(II) CONTAINING COMPLEX AND CONDENSATION REACTION CATALYSTS, METHODS FOR PREPARING THE CATALYSTS, AND COMPOSITIONS CONTAINING THE CATALYSTS DOW CORNING CORPORATION (US) 2013-04-11 WO disclosed