Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 2/20 | 0.61 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.61 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.61 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | CDK9 | P50750 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14086882 | 0.85 | PDK1 (0.65) | PDK1PDK2PDK3PDK4L3MBTL1 | |
| SCHEMBL14849461 | 0.84 | PDK1 (0.63) | PDK1PDK2PDK3PDK4L3MBTL1 | |
| SCHEMBL83110 | 0.84 | L3MBTL1 (0.78) | PDK1PDK2PDK3PDK4L3MBTL1 | |
| SCHEMBL11172475 | 0.83 | MAPT (0.59) | PDK1PDK2PDK3PDK4L3MBTL1 | |
| SCHEMBL3129785 | 0.83 | PDK1 (0.67) | PDK1PDK2PDK3PDK4L3MBTL1 | |
| SCHEMBL10974469 | 0.82 | TP53 (0.58) | PDK1PDK2PDK3PDK4L3MBTL1 | |
| SCHEMBL10989896 | 0.81 | MAPT (0.61) | PDK1PDK2PDK3PDK4L3MBTL1 | |
| SCHEMBL16212234 | 0.81 | PDK1 (0.70) | PDK1PDK2PDK3PDK4L3MBTL1 | |
| SCHEMBL3654999 | 0.81 | PDK1 (0.59) | PDK1PDK2PDK3PDK4L3MBTL1 | |
| SCHEMBL2745516 | 0.81 | PDK1 (0.59) | PDK1PDK2PDK3PDK4L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4473694-A | Process for the preparation of polysubstituted α-aminoacetamides | THE B. F. GOODRICH COMPANY (US) | 1984-09-25 | — | — | US | claimed |
| EP-0062322-A1 | Improved process for synthesis of hindered amine stabilizers for polymeric materials | The B.F. GOODRICH Company (US) | 1982-10-13 | — | — | EP | claimed |
| US-10428051-B2 | Substituted amide derivatives having multimodal activity against pain | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2019-10-01 | — | — | US | disclosed |
| US-10428051-B2 | Substituted amide derivatives having multimodal activity against pain | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2019-10-01 | — | — | US | disclosed |
| EP-2596062-B1 | SET-LRP POLYMERIZATION OF ACRYLATES IN THE PRESENCE OF ACIDS | ROHM & HAAS (US) | 2019-09-18 | — | — | EP | disclosed |
| EP-3328853-B1 | SUBSTITUTED AMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS SA (ES) | 2019-09-11 | — | — | EP | disclosed |
| EP-3328853-B1 | SUBSTITUTED AMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS SA (ES) | 2019-09-11 | — | — | EP | disclosed |
| US-10273314-B2 | Set-LRP polymerization of acrylates in the presence of acids | ROHM AND HAAS COMPANY (US) | 2019-04-30 | — | — | US | disclosed |
| US-20190002443-A1 | SUBSTITUTED AMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2019-01-03 | — | — | US | disclosed |
| US-20190002443-A1 | SUBSTITUTED AMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2019-01-03 | — | — | US | disclosed |
| EP-2968995-B1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | ELAN PHARMACEUTICALS LLC (US) | 2018-05-09 | — | — | EP | disclosed |
| CN-1382124-A | Bicyclic androgen and progesterone receptor modulating compounds and methods | LIGAND PHARM INC (US) | 2002-11-27 | — | — | CN | disclosed |
| US-4818755-A | Bicyclic heteroaryl thiazole compounds, cardiotonic compositions including the same, and their uses | RORER PHARMACEUTICAL CORPORATON (US) | 1989-04-04 | — | — | US | disclosed |
| EP-0207140-A4 | BICYCLIC HETEROARYL THIAZOLE COMPOUNDS, CARDIOTONIC COMPOSITIONS INCLUDING THE SAME, AND THEIR USES. | RORER INTERNAT OVERSEAS INC (US) | 1987-06-15 | — | — | EP | disclosed |
| EP-0207140-A1 | BICYCLIC HETEROARYL THIAZOLE COMPOUNDS, CARDIOTONIC COMPOSITIONS INCLUDING THE SAME, AND THEIR USES | RORER INTERNATIONAL (OVERSEAS) INC. (a Delaware corporation) (US) | 1987-01-07 | — | — | EP | disclosed |
| WO-1986003749-A1 | BICYCLIC HETEROARYL THIAZOLE COMPOUNDS, CARDIOTONIC COMPOSITIONS INCLUDING THE SAME, AND THEIR USES | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1986-07-03 | — | — | WO | disclosed |
| US-4500662-A | STABILIZERS OF POLYMERIC MATERIALS AGAINST ULTRAVIOLET DEGRADATION | THE B. F. GOODRICH COMPANY (US) | 1985-02-19 | — | — | US | disclosed |
| US-4473694-A | Process for the preparation of polysubstituted α-aminoacetamides | THE B. F. GOODRICH COMPANY (US) | 1984-09-25 | — | — | US | disclosed |
| EP-0062322-A1 | Improved process for synthesis of hindered amine stabilizers for polymeric materials | The B.F. GOODRICH Company (US) | 1982-10-13 | — | — | EP | disclosed |
| US-4258196-A | REACTING THE ANION OF A PRIMARY OR SECONDARY 2-HALOACETAMIDE WITH AN ALKYLATING AGENT | MONSANTO COMPANY (US) | 1981-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10428051-B2 | Substituted amide derivatives having multimodal activity against pain | OPRM1, OPRD1, OPRK1 | PDK1 3528/4885PDK2 3774/4885PDK3 3232/4885 |
| US-20190002443-A1 | SUBSTITUTED AMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | OPRM1, OPRD1, OPRK1 | PDK1 3528/4885PDK2 3774/4885PDK3 3232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.