Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 1/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.32 |
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | MITF | O75030 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.30 |
| ▸ | MC4R | P32245 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15959063 | 0.86 | CASR (0.37) | CASRITGB1ITGA4ITGB7OPRK1 | |
| SCHEMBL13638260 | 0.79 | ALDH1A1 (0.35) | CASRKMT2AMITFALDH1A1LMNA | |
| SCHEMBL13953687 | 0.76 | CASR (0.38) | CASRKMT2AMITFALDH1A1LMNA | |
| SCHEMBL957448 | 0.76 | CASR (0.38) | CASRKMT2AMITFALDH1A1LMNA | |
| SCHEMBL15368397 | 0.73 | GPR139 (0.35) | ALDH1A1LMNAHTTGPR139 | |
| SCHEMBL13953572 | 0.73 | MTNR1A (0.33) | CASRKMT2AMITFALDH1A1LMNA | |
| SCHEMBL13624881 | 0.72 | LPL (0.40) | KMT2AMITFALDH1A1LMNAMAPT | |
| SCHEMBL13552181 | 0.71 | HSD11B1 (0.47) | HSD11B1 | |
| SCHEMBL1904136 | 0.70 | HTT (0.35) | CASRHSD11B1KMT2AMITFALDH1A1 | |
| SCHEMBL15959034 | 0.69 | CASR (0.41) | CASRHSD11B1KMT2AMITFALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300461-B1 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS INC (US) | 2013-04-17 | — | — | EP | disclosed |