Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 2/20 | 0.75 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.66 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.59 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18087475 | 0.88 | MEN1 (0.76) | NQO2KCNK3KCNK9KMT2AMEN1 | |
| SCHEMBL28423699 | 0.88 | KCNK3 (0.66) | NQO2KCNK3KCNK9KDM4EPOLB | |
| SCHEMBL22305399 | 0.87 | KCNK3 (0.83) | KCNK3KCNK9KDM4EPOLBHTT | |
| SCHEMBL6027801 | 0.86 | NQO2 (1.00) | NQO2KDM4EPOLBLMNAGAA | |
| SCHEMBL2385408 | 0.85 | KMT2A (0.83) | KCNK3KCNK9POLBLMNAKMT2A | |
| SCHEMBL4740949 | 0.84 | NQO2 (0.75) | NQO2KCNK3KCNK9KDM4EPOLB | |
| SCHEMBL28218533 | 0.84 | NQO2 (0.54) | NQO2KCNK3KCNK9KDM4EPOLB | |
| SCHEMBL28218896 | 0.84 | PGR (0.67) | NQO2KCNK3KCNK9HTTKMT2A | |
| SCHEMBL679222 | 0.82 | DEGS1 (0.79) | NQO2KDM4EPOLBPTPN1KMT2A | |
| N-Phenylbenzamide SCHEMBL27671345 | 0.82 | POLB (0.71) | KCNK3KCNK9KDM4EPOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4385147-A | Stabilization of chlorine-containing thermoplastics with m-aminophenol derivatives | CIBA-GEIGY CORPORATION (US) | 1983-05-24 | — | — | US | claimed |
| CN-113817150-B | Copolyester containing aromatic secondary amine structure and preparation method and application thereof | 四川大学 | 2022-06-21 | — | — | CN | disclosed |
| CN-113817150-A | Copolyester containing aromatic secondary amine structure and preparation method and application thereof | 四川大学 | 2021-12-21 | — | — | CN | disclosed |
| EP-2362226-A1 | Diagnostic method for neurodegenerative diseases based on measurement of SIRT1 levels or activity | The President and Fellows of Harvard College (US) | 2011-08-31 | — | — | EP | disclosed |
| EP-2289504-A2 | SIRT1 modulators for manipulating cell/organism lifespan/stress response | President and Fellows of Harvard College (US) | 2011-03-02 | — | — | EP | disclosed |
| EP-2236131-A2 | Compositions for manipulating the lifespan and stress response of cells and organisms | President and Fellows of Harvard College (US) | 2010-10-06 | — | — | EP | disclosed |
| US-20100035885-A1 | COMPOSITIONS FOR MANIPULATING THE LIFESPAN AND STRESS RESPONSE OF CELLS AND ORGANISMS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-02-11 | — | — | US | disclosed |
| US-7544497-B2 | Compositions for manipulating the lifespan and stress response of cells and organisms | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-06-09 | — | — | US | disclosed |
| EP-1863461-A2 | SIRTUIN RELATED THERAPEUTICS AND DIAGNOSTICS FOR NEURODEGENERATIVE DISEASES | The President and Fellows of Harvard College (US) | 2007-12-12 | — | — | EP | disclosed |
| EP-1850840-A2 | NOVEL COMPOSITIONS FOR PREVENTING AND TREATING NEURODEGENERATIVE AND BLOOD COAGULATION DISORDERS | Sirtris Pharmaceuticals, Inc. (US) | 2007-11-07 | — | — | EP | disclosed |
| EP-1648437-A2 | SIRT1 MODULATORS FOR MANIPULATING CELL/ORGANISM LIFESPAN/STRESS RESPONSE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2006-04-26 | — | — | EP | disclosed |
| US-20060084135-A1 | Compositions for manipulating the lifespan and stress response of cells and organisms | BIOMOL INTERNATIONAL, INC. | 2006-04-20 | — | — | US | disclosed |
| US-20060025337-A1 | Sirtuin related therapeutics and diagnostics for neurodegenerative diseases | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2006-02-02 | — | — | US | disclosed |
| US-20050136537-A1 | Compositions for manipulating the lifespan and stress response of cells and organisms | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2005-06-23 | — | — | US | disclosed |
| US-20050096256-A1 | Compositions for manipulating the lifespan and stress response of cells and organisms | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2005-05-05 | — | — | US | disclosed |
| WO-2005002672-A2 | SIRT1 MODULATORS FOR MANIPULATING CELLS/ORGANISM LIFESPAN/STRESS RESPONSE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2005-01-13 | — | — | WO | disclosed |
| WO-2005002555-A2 | SIRT1 MODULATORS FOR MANIPULATING CELL/ORGANISM LIFESPAN/STRESS RESPONSE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2005-01-13 | — | — | WO | disclosed |
| EP-0048222-B1 | STABILISATION OF THERMOPLASTICS THAT CONTAIN CHLORINE WITH M-AMINO PHENOLS | CIBA-GEIGY AG (CH) | 1984-12-27 | — | — | EP | disclosed |
| US-4385147-A | Stabilization of chlorine-containing thermoplastics with m-aminophenol derivatives | CIBA-GEIGY CORPORATION (US) | 1983-05-24 | — | — | US | disclosed |
| EP-0048222-A1 | Stabilisation of thermoplastics that contain chlorine with m-amino phenols | CIBA-GEIGY AG (CH) | 1982-03-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035885-A1 | COMPOSITIONS FOR MANIPULATING THE LIFESPAN AND STRESS RESPONSE OF CELLS AND ORGANISMS | SIRT1, SIRT2, FOXO3 | NQO2 2310/4885KCNK3 3255/4885KCNK9 3912/4885 |
| US-20060025337-A1 | Sirtuin related therapeutics and diagnostics for neurodegenerative diseases | SIRT1, SIRT2, SIRT3 | NQO2 1035/4885KCNK3 2440/4885KCNK9 3028/4885 |
| US-20050096256-A1 | Compositions for manipulating the lifespan and stress response of cells and organisms | SIRT1, SIRT2, FOXO3 | NQO2 2310/4885KCNK3 3255/4885KCNK9 3912/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.