SCHEMBL148782

SCHEMBL148782

CCOC(=O)CC(Cl)(Cl)CO

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.46
MGAM O43451 1/20 0.46
SI P14410 1/20 0.46
MGAM2 Q2M2H8 1/20 0.46
ALDH1A1 P00352 3/20 0.43
TRPA1 O75762 1/20 0.43
CYP1A2 P05177 1/20 0.38
KDM4E B2RXH2 1/20 0.37
PKM P14618 1/20 0.37
GSK3A P49840 1/20 0.37
GSK3B P49841 1/20 0.37
LMNA P02545 1/20 0.37
HSD17B10 Q99714 1/20 0.37
ALOX15 P16050 1/20 0.36
SOAT1 P35610 1/20 0.36
CYP4F2 P78329 4/20 0.35
CYP4A11 Q02928 4/20 0.35
CA12 O43570 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methylene Chloride SCHEMBL3176439 0.96 GAA (0.43) GAAMGAMSIMGAM2ALDH1A1
Heptane SCHEMBL6925620 0.91 NAAA (0.40) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL5864262 0.83 GAA (0.43) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL10723443 0.81 GAA (0.44) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL4288701 0.81 GAA (0.44) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL181945 0.79 GAA (0.52) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL8820595 0.77 GAA (0.50) GAAMGAMSIMGAM2ALDH1A1
Ethyl Acetate SCHEMBL7646921 0.76 ALDH1A1 (0.52) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL4341048 0.76 MEN1 (0.42) GAAMGAMSIMGAM2ALDH1A1
SCHEMBL3967529 0.76 MEN1 (0.41) GAAMGAMSIMGAM2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 404 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116675636-A Near-infrared two-photon dual-mode linkage response NTR & Cys fluorescent probe and preparation method and application thereof 江苏辛巴生物医药有限公司 2023-09-01 CN claimed
US-8883167-B2 Ethanol extract of Antrodia camphorata for inducing apoptosis and preparation method thereof KAOHSIUNG MEDICAL UNIVERSITY (TW) 2014-11-11 US claimed
US-20120141524-A1 ETHANOL EXTRACT OF ANTRODIA CAMPHORATA FOR INDUCING APOPTOSIS AND PREPARATION METHOD THEREOF KAOHSIUNG MEDICAL UNIVERSITY (TW) 2012-06-07 US claimed
US-20100210869-A1 ETHANOL EXTRACT OF ANTRODIA CAMPHORATA FOR INDUCING APOPTOSIS AND PREPARATION METHOD THEREOF KAOHSIUNG MEDICAL UNIVERSITY (TW) 2010-08-19 US claimed
CN-118221669-A Derivatives as DNA polymerase Theta inhibitors 艾立康药业股份有限公司 2024-06-21 CN disclosed
CN-118063445-A Pyrrolidine amide derivatives and use thereof 广东东阳光药业股份有限公司 2024-05-24 CN disclosed
CN-118063444-A Azetidinamide derivatives and uses thereof 广东东阳光药业股份有限公司 2024-05-24 CN disclosed
US-11969469-B2 Pharmaceutical compositions having improved storage stability ALKERMES PHARMA IRELAND LIMITED (IE) 2024-04-30 US disclosed
US-20240131024-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING SORBITAN ESTERS JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT 2024-04-25 US disclosed
EP-4349832-A1 CHEMICAL COUPLING LINKER AND USE THEREOF Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) 2024-04-10 EP disclosed
US-20240109917-A1 PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS ACTELION PHARMACEUTICALS LTD (CH) 2024-04-04 US disclosed
US-11931355-B2 Aripiprazole formulations having increased injection speeds ALKERMES PHARMA IRELAND LIMITED (IE) 2024-03-19 US disclosed
EP-0514193-A1 N-linked imidazolyl-methyl benzofuran derivatives with antihypotensive activity GLAXO GROUP LIMITED (GB) 1992-11-19 EP disclosed
EP-0144729-B1 11-Substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines, a process for their preparation and their use in medicaments HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1989-11-08 EP disclosed
US-4855307-A Acetic acid ester of haloperidol H. LUNDBECK A/S (DK) 1989-08-08 US disclosed
US-4681879-A 11-substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines as antipsychotic and analgesic agents HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1987-07-21 US disclosed
EP-0204317-A2 2-Thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters E.R. Squibb & Sons, Inc. (US) 1986-12-10 EP disclosed
US-4608374-A 11-substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines as antipsychotic and analgesic agents HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1986-08-26 US disclosed
EP-0144729-A1 11-Substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines, a process for their preparation and their use in medicaments HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1985-06-19 EP disclosed
US-4061655-A ANTIINFLAMMATORY E. R. SQUIBB & SONS, INC. (US) 1977-12-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11931355-B2 Aripiprazole formulations having increased injection speeds CYP2C19, ATP6V1B2, CYP2D6 GAA 2185/4885MGAM 2148/4885SI 798/4885
US-11969469-B2 Pharmaceutical compositions having improved storage stability TREH, CTSA, MAOA GAA 14/4885MGAM 312/4885SI 421/4885
US-20240131024-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING SORBITAN ESTERS SORBS1, ABCG2, FABP7 GAA 111/4885MGAM 984/4885SI 292/4885
US-20120141524-A1 ETHANOL EXTRACT OF ANTRODIA CAMPHORATA FOR INDUCING APOPTOSIS AND PREPARATION METHOD THEREOF BAX, API5, BCL2 GAA 1854/4885MGAM 3379/4885SI 118/4885
US-20100210869-A1 ETHANOL EXTRACT OF ANTRODIA CAMPHORATA FOR INDUCING APOPTOSIS AND PREPARATION METHOD THEREOF BAX, API5, BCL2 GAA 1854/4885MGAM 3379/4885SI 118/4885
US-20240109917-A1 PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS PDGFRA, PDGFRB, ABL1 GAA 1529/4885MGAM 4424/4885SI 4063/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.