Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MMP3 | P08254 | 5/20 | 0.39 |
| ▸ | MMP1 | P03956 | 4/20 | 0.39 |
| ▸ | MMP9 | P14780 | 4/20 | 0.39 |
| ▸ | MMP7 | P09237 | 3/20 | 0.39 |
| ▸ | MMP13 | P45452 | 3/20 | 0.39 |
| ▸ | MMP8 | P22894 | 2/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12905432 | 0.91 | ALDH1A1 (0.39) | KMT2AMEN1MMP3MMP1MMP9 | |
| SCHEMBL14878480 | 0.91 | MMP9 (0.47) | KMT2AMMP3MMP1MMP9MMP7 | |
| SCHEMBL14878481 | 0.90 | MMP3 (0.41) | KMT2AMMP3MMP1MMP9MMP7 | |
| SCHEMBL779155 | 0.89 | MMP1 (0.52) | MMP3MMP1MMP9MMP7MMP13 | |
| SCHEMBL14878434 | 0.89 | MMP1 (0.36) | KMT2AMEN1MMP3MMP1MMP9 | |
| SCHEMBL14878453 | 0.85 | MMP1 (0.37) | KMT2AMEN1MMP3MMP1MMP9 | |
| SCHEMBL14878418 | 0.85 | F10 (0.42) | KMT2AMMP3MMP1MMP9MMP7 | |
| SCHEMBL14878402 | 0.84 | ITGA4 (0.37) | KMT2AMMP3MMP1MMP9MMP7 | |
| SCHEMBL14878401 | 0.84 | KMT2A (0.41) | KMT2AMMP3MMP1MMP9MMP7 | |
| SCHEMBL14878440 | 0.84 | ALDH1A1 (0.37) | KMT2AMMP3MMP1MMP9MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511488-B1 | HUMAN ADAM-10 INHIBITORS | SYMPHONY EVOLUTION INC (US) | 2013-05-22 | — | — | EP | disclosed |
| US-8426415-B2 | Human ADAM-10 inhibitors | SYMPHONY EVOLUTION, INC. (US) | 2013-04-23 | — | — | US | disclosed |
| EP-2436676-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-04-04 | — | — | EP | disclosed |