Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | PGR | P06401 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21268669 | 0.90 | NOTUM (0.42) | PTGS2PTGS1NOTUMCYP11B2CYP17A1 | |
| SCHEMBL15516729 | 0.80 | PTGS2 (0.41) | PTGS2PTGS1ALDH1A1HTT | |
| SCHEMBL15516726 | 0.80 | PTGS2 (0.51) | PTGS2PTGS1PGR | |
| SCHEMBL12473617 | 0.77 | KIF11 (0.55) | PTGS2PTGS1CYP11B2CYP11B1 | |
| SCHEMBL13741967 | 0.76 | CYP17A1 (0.52) | PTGS2PTGS1NOTUMCYP11B2CYP17A1 | |
| SCHEMBL15516319 | 0.75 | PTGS2 (0.46) | PTGS2PTGS1 | |
| SCHEMBL19993855 | 0.74 | SLC6A3 (0.40) | PTGS2PTGS1CYP11B2CYP11B1HRH3 | |
| SCHEMBL19993948 | 0.74 | PTGS2 (0.46) | PTGS2PTGS1PGR | |
| SCHEMBL1257285 | 0.73 | ACMSD (0.49) | PTGS2PTGS1CYP11B2CYP17A1CYP11B1 | |
| SCHEMBL8638170 | 0.73 | MLNR (0.39) | PTGS2PTGS1NOTUMPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103140476-A | Novel trpv3 modulators | ABBOTT LAB | 2013-06-05 | — | — | CN | claimed |
| CN-104254522-A | Methanol derivatives as trpv3 modulators | ABBVIE INC | 2014-12-31 | — | — | CN | disclosed |
| CN-103140476-A | Novel trpv3 modulators | ABBOTT LAB | 2013-06-05 | — | — | CN | disclosed |
| WO-2013062966-A2 | NOVEL TRPV3 MODULATORS | ABBVIE INC. (US) | 2013-05-02 | — | — | WO | disclosed |