SCHEMBL15516319

SCHEMBL15516319

Fc1cc([C]2CCC2)cc(F)c1F

nearest known ligand 0.46

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 6/20 0.46
PTGS1 P23219 2/20 0.34
CES2 O00748 1/20 0.33
CES1 P23141 1/20 0.33
MAPK14 Q16539 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15516019 0.89 PTGS2 (0.40) PTGS2CES2CES1
SCHEMBL15517103 0.75 PTGS2 (0.37) PTGS2PTGS1
SCHEMBL14895682 0.75 PTGS2 (0.47) PTGS2PTGS1
SCHEMBL1525706 0.73 CES2 (0.45) PTGS2CES2CES1
SCHEMBL15516729 0.70 PTGS2 (0.41) PTGS2PTGS1
SCHEMBL12473617 0.68 KIF11 (0.55) PTGS2PTGS1
SCHEMBL15517234 0.67 PGR (0.37) PTGS2PTGS1MAPK14
SCHEMBL8076761 0.66 ACMSD (0.40) PTGS2
SCHEMBL15516241 0.66 PTGS2 (0.33) PTGS2
SCHEMBL15516726 0.66 PTGS2 (0.51) PTGS2PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2887802-A2 METHODS OF SOIL PEST CONTROL Syngenta Participations AG (CH) 2015-07-01 EP disclosed
WO-2014029706-A2 METHODS OF CONTROLLING INSECTS SYNGENTA PARTICIPATIONS AG (CH) 2014-02-27 WO disclosed
WO-2014029708-A1 METHODS OF CONTROLLING INSECTS SYNGENTA PARTICIPATIONS AG (CH) 2014-02-27 WO disclosed
WO-2014029707-A1 METHODS OF CONTROLLING INSECTS SYNGENTA PARTICIPATIONS AG (CH) 2014-02-27 WO disclosed
WO-2014029710-A2 METHODS OF SOIL PEST CONTROL SYNGENTA PARTICIPATIONS AG (CH) 2014-02-27 WO disclosed
WO-2014019609-A1 METHODS OF PEST CONTROL IN SOYBEAN SYNGENTA PARTICIPATIONS AG (CH) 2014-02-06 WO disclosed