SCHEMBL14904608

SCHEMBL14904608

CSCC(C)C(=O)N(C)c1cnn(-c2cccnc2)c1

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.37
PRMT5 O14744 1/20 0.36
TGFBR1 P36897 1/20 0.36
RIPK2 O43353 3/20 0.35
ALDH1A1 P00352 1/20 0.35
CYP2A6 P11509 1/20 0.35
ERCC5 P28715 1/20 0.34
TAS2R8 Q9NYW2 2/20 0.34
MTOR P42345 2/20 0.34
GRM1 Q13255 1/20 0.33
RPTOR Q8N122 1/20 0.33
MLST8 Q9BVC4 1/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
TRPV1 Q8NER1 1/20 0.33
ADORA2A P29274 1/20 0.32
ADORA2B P29275 1/20 0.32
ADORA1 P30542 1/20 0.32
TBXAS1 P24557 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2690115 0.86 CYP2A6 (0.39) LMNAPRMT5TGFBR1RIPK2CYP2A6
SCHEMBL14904691 0.81 NPC1 (0.36) LMNAALDH1A1CYP2A6GRM1NPC1
SCHEMBL15975571 0.81 ALDH1A1 (0.38) PRMT5TGFBR1RIPK2ALDH1A1CYP2A6
SCHEMBL15363512 0.80 LMNA (0.35) LMNAPRMT5ALDH1A1CYP2A6GRM1
SCHEMBL14904649 0.80 LMNA (0.35) LMNAALDH1A1GRM1NPC1RAB9A
SCHEMBL2732597 0.80 CYP2A6 (0.42) PRMT5TGFBR1RIPK2ALDH1A1CYP2A6
SCHEMBL4965578 0.80 CYP2A6 (0.42) PRMT5TGFBR1RIPK2CYP2A6ERCC5
SCHEMBL15975568 0.79 RIPK1 (0.37) PRMT5TGFBR1RIPK2ALDH1A1CYP2A6
SCHEMBL15910357 0.79 TGFBR1 (0.34) LMNAPRMT5TGFBR1RIPK2ALDH1A1
SCHEMBL15910360 0.77 CYP2A6 (0.39) PRMT5TGFBR1RIPK2ALDH1A1CYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10165775-B2 Pesticidal compositions and processes related thereto DOW AGROSCIENCES LLC (US) 2019-01-01 US disclosed
US-9708288-B2 Pesticidal compositions and processes related thereto DOW AGROSCIENCES LLC (US) 2017-07-18 US disclosed
US-9708288-B2 Pesticidal compositions and processes related thereto DOW AGROSCIENCES LLC (US) 2017-07-18 US disclosed
US-9655365-B2 Pesticidal compositions and processes related thereto DOW AGROSCIENCES LLC (US) 2017-05-23 US disclosed
US-9655365-B2 Pesticidal compositions and processes related thereto DOW AGROSCIENCES LLC (US) 2017-05-23 US disclosed
US-9591857-B2 Pesticidal compositions and processes related thereto DOW AGROSCIENCES LLC (US) 2017-03-14 US disclosed
US-9591857-B2 Pesticidal compositions and processes related thereto DOW AGROSCIENCES LLC (US) 2017-03-14 US disclosed
US-9422278-B2 Pesticidal compositions and processes related thereto DOW AGROSCIENCES LLC (US) 2016-08-23 US disclosed
US-9422278-B2 Pesticidal compositions and processes related thereto DOW AGROSCIENCES LLC (US) 2016-08-23 US disclosed
US-9282739-B2 Pesticidal compositions and processes related thereto DOW AGROSCIENCES LLC (US) 2016-03-15 US disclosed
US-20150072859-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2015-03-12 US disclosed
US-8937083-B2 Pesticidal compositions and processes related thereto DowAgroSciences, LLC (US) 2015-01-20 US disclosed
US-8937083-B2 Pesticidal compositions and processes related thereto DowAgroSciences, LLC (US) 2015-01-20 US disclosed
US-8901153-B2 Pesticidal compositions and processes related thereto DOW AGROSCIENCES, LLC. (US) 2014-12-02 US disclosed
US-8901153-B2 Pesticidal compositions and processes related thereto DOW AGROSCIENCES, LLC. (US) 2014-12-02 US disclosed
US-8815271-B2 Pesticidal compositions and processes related thereto DOW AGROSCIENCES, LLC. (US) 2014-08-26 US disclosed
US-8815271-B2 Pesticidal compositions and processes related thereto DOW AGROSCIENCES, LLC. (US) 2014-08-26 US disclosed
US-20130109566-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2013-05-02 US disclosed
WO-2013062981-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2013-05-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130109566-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, PTMS LMNA 2810/4885PRMT5 1049/4885TGFBR1 1799/4885
US-20150072859-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, PTMS LMNA 2810/4885PRMT5 1049/4885TGFBR1 1799/4885
US-10165775-B2 Pesticidal compositions and processes related thereto ACHE, DDT, PTMS LMNA 2810/4885PRMT5 1049/4885TGFBR1 1799/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.