Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 6/20 | 0.60 |
| ▸ | WDR5 | P61964 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | RBBP5 | Q15291 | 3/20 | 0.54 |
| ▸ | DPY30 | Q9C005 | 3/20 | 0.54 |
| ▸ | ASH2L | Q9UBL3 | 3/20 | 0.54 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.51 |
| ▸ | AHCY | P23526 | 1/20 | 0.51 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.51 |
| ▸ | GNMT | Q14749 | 1/20 | 0.47 |
| ▸ | EZH2 | Q15910 | 3/20 | 0.47 |
| ▸ | NNMT | P40261 | 2/20 | 0.47 |
| ▸ | NSD2 | O96028 | 2/20 | 0.46 |
| ▸ | PCMT1 | P22061 | 2/20 | 0.46 |
| ▸ | SETD7 | Q8WTS6 | 2/20 | 0.46 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.46 |
| ▸ | TRDMT1 | O14717 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | RNMT | O43148 | 1/20 | 0.46 |
| ▸ | INMT | O95050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14905981 | 0.94 | DOT1L (0.58) | DOT1LWDR5KMT2ARBBP5DPY30 | |
| SCHEMBL14905991 | 0.80 | CARM1 (0.59) | DOT1LAHCYCARM1NNMTNSD2 | |
| SCHEMBL5184094 | 0.79 | DOT1L (0.76) | DOT1LWDR5KMT2ARBBP5DPY30 | |
| Formic Acid SCHEMBL5184915 | 0.78 | DOT1L (0.72) | DOT1LWDR5KMT2ARBBP5DPY30 | |
| SCHEMBL14905924 | 0.78 | PRMT6 (0.50) | DOT1LWDR5KMT2ARBBP5DPY30 | |
| SCHEMBL16154125 | 0.77 | DOT1L (0.59) | DOT1LWDR5KMT2ARBBP5DPY30 | |
| SCHEMBL5184990 | 0.75 | AHCY (0.62) | DOT1LWDR5KMT2ARBBP5DPY30 | |
| SCHEMBL10887920 | 0.74 | DOT1L (0.62) | DOT1LPLA2G2AAHCY | |
| SCHEMBL14905933 | 0.73 | ADORA1 (0.51) | DOT1LPLA2G2A | |
| SCHEMBL4727574 | 0.73 | MARS1 (0.61) | DOT1LWDR5KMT2ARBBP5DPY30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2771343-B1 | METHYLTRANSFERASE INHIBITORS FOR TREATING CANCER | SLOAN KETTERING INST CANCER (US) | 2016-07-13 | — | — | EP | disclosed |
| WO-2013063417-A1 | METHYLTRANSFERASE INHIBITORS FOR TREATING CANCER | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2013-05-02 | — | — | WO | disclosed |