Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 6/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.32 |
| ▸ | RET | P07949 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19682258 | 0.82 | MAOA (0.39) | CHRM1MAOAKMT2AMEN1KDM4E | |
| SCHEMBL20272361 | 0.81 | CHRM1 (0.37) | CHRM1MAOAKMT2AMEN1KDM4E | |
| SCHEMBL21784415 | 0.79 | MEN1 (0.39) | CHRM1MAOAKMT2AMEN1KDM4E | |
| SCHEMBL16281504 | 0.76 | ACHE (0.40) | MAOAKMT2AMEN1KDM4EBCHE | |
| SCHEMBL20198315 | 0.71 | MAOA (0.46) | MAOAKDM4EBCHECES1CYP1A2 | |
| SCHEMBL27726559 | 0.70 | — | — | |
| SCHEMBL27855844 | 0.69 | MAOA (0.56) | CHRM1MAOAKMT2AMEN1KDM4E | |
| SCHEMBL11785699 | 0.66 | MAPT (0.50) | MAOAKMT2AMEN1KDM4EBCHE | |
| SCHEMBL11785702 | 0.66 | MAPT (0.50) | MAOAKMT2AMEN1KDM4EBCHE | |
| SCHEMBL17472428 | 0.66 | MAOA (0.38) | CHRM1MAOAKMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160324973-A1 | COMPOSITION COMPRISING A POLYMERIC REAGENT | NEKTAR THERAPEUTICS | 2016-11-10 | — | — | US | disclosed |
| US-9381254-B2 | Methods for preparing polymeric reagents | NEKTAR THERAPEUTICS (US) | 2016-07-05 | — | — | US | disclosed |
| US-20160022830-A1 | METHODS FOR PREPARING POLYMERIC REAGENTS | NEKTAR THERAPEUTICS | 2016-01-28 | — | — | US | disclosed |
| US-20150141665-A1 | METHODS FOR PREPARING POLYMERIC REAGENTS | NEKTAR THERAPEUTICS (US) | 2015-05-21 | — | — | US | disclosed |
| US-8703115-B2 | Methods for preparing conjugates | NEKTAR THERAPEUTICS (US) | 2014-04-22 | — | — | US | disclosed |
| US-8435505-B2 | Pharmaceutical compositions and methods for delivering such compositions | NEKTAR THERAPEUTICS (US) | 2013-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160324973-A1 | COMPOSITION COMPRISING A POLYMERIC REAGENT | CAT, LPO, GPX4 | CHRM1 4515/4885MAOA 221/4885KMT2A 2707/4885 |
| US-20150141665-A1 | METHODS FOR PREPARING POLYMERIC REAGENTS | PAM, ALKBH3, DNPEP | CHRM1 2540/4885MAOA 1085/4885KMT2A 1128/4885 |
| US-20160022830-A1 | METHODS FOR PREPARING POLYMERIC REAGENTS | PAM, ALKBH3, DNPEP | CHRM1 2540/4885MAOA 1085/4885KMT2A 1128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.