Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7309866 | 0.81 | GABRA1 (0.38) | ALDH1A1 | |
| SCHEMBL407499 | 0.75 | PSMD14 (0.36) | — | |
| SCHEMBL558260 | 0.75 | PARP1 (0.34) | ALDH1A1 | |
| SCHEMBL4623912 | 0.71 | METAP2 (0.35) | ALDH1A1POLB | |
| SCHEMBL1264261 | 0.71 | TDP1 (0.40) | ALDH1A1POLB | |
| SCHEMBL1886180 | 0.71 | PSMB8 (0.41) | — | |
| SCHEMBL1888862 | 0.70 | AXL (0.43) | ALDH1A1POLB | |
| SCHEMBL16097482 | 0.68 | IDO1 (0.42) | — | |
| SCHEMBL19283857 | 0.67 | KEAP1 (0.37) | ALDH1A1 | |
| SCHEMBL557929 | 0.67 | KEAP1 (0.44) | ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300427-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2011-03-30 | — | — | EP | claimed |
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | claimed |
| EP-2300427-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |