Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | MME | P08473 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 10/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | ACE | P12821 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25381544 | 0.86 | ATM (0.37) | ATMCTSSDGAT1 | |
| SCHEMBL27285081 | 0.81 | ATM (0.33) | ATMCTSS | |
| SCHEMBL31276598 | 0.80 | ATM (0.35) | ATMCTSS | |
| SCHEMBL26251293 | 0.80 | ATM (0.56) | ATMMMEPIK3CDACE | |
| SCHEMBL3070231 | 0.80 | CTSS (0.42) | CTSS | |
| SCHEMBL27393371 | 0.79 | ATM (0.34) | ATMCTSSACE | |
| SCHEMBL27285282 | 0.77 | ATM (0.33) | ATM | |
| SCHEMBL14938155 | 0.77 | ATM (0.61) | ATMMMEPIK3CDACE | |
| SCHEMBL3662304 | 0.76 | ATM (0.59) | ATMMMEPIK3CDACE | |
| SCHEMBL27285075 | 0.76 | ATM (0.32) | ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108699044-B | Novel pyrrolidine derivatives | 豪夫迈·罗氏有限公司 | 2022-03-04 | — | — | CN | disclosed |
| US-10689339-B2 | Pyrrolidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2020-06-23 | — | — | US | disclosed |
| US-20180362461-A1 | NOVEL PYRROLIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2018-12-20 | — | — | US | disclosed |
| EP-2776392-B1 | PROCESS FOR THE PREPARATION OF 1-ACYL-4-PHENYLSULFONYLPROLINAMIDE DERIVATIVES AND NEW INTERMEDIATES | HOFFMANN LA ROCHE (CH) | 2016-05-18 | — | — | EP | disclosed |
| EP-2776392-A1 | PROCESS FOR THE PREPARATION OF 1-ACYL-4-PHENYLSULFONYLPROLINAMIDE DERIVATIVES AND NEW INTERMEDIATES | F.HOFFMANN-LA ROCHE AG (CH) | 2014-09-17 | — | — | EP | disclosed |
| US-8796471-B2 | Process for the preparation of proline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2014-08-05 | — | — | US | disclosed |
| US-20130123512-A1 | PROCESS FOR THE PREPARATION OF PROLINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2013-05-16 | — | — | US | disclosed |
| WO-2013068434-A1 | PROCESS FOR THE PREPARATION OF 1-ACYL-4-PHENYLSULFONYLPROLINAMIDE DERIVATIVES AND NEW INTERMEDIATES | F. HOFFMANN-LA ROCHE AG (CH) | 2013-05-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180362461-A1 | NOVEL PYRROLIDINE DERIVATIVES | ARG2, PYCR1, ARG1 | ATM 3383/4885MME 4698/4885CTSS 2797/4885 |
| US-20130123512-A1 | PROCESS FOR THE PREPARATION OF PROLINE DERIVATIVES | CTSS, CTSV, CTSZ | ATM 2839/4885MME 485/4885CTSS 1/4885 |
| US-10689339-B2 | Pyrrolidine derivatives | PYCR1, AVPR2, ARG2 | ATM 3201/4885MME 4541/4885CTSS 2385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.