Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 3/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | DBH | P09172 | 1/20 | 0.41 |
| ▸ | ACP3 | P15309 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL27657596 | 1.00 | HDAC4 (0.47) | HDAC4HDAC2HDAC8BACE1ALDH1A1 | |
| Resorcinol SCHEMBL17060537 | 0.90 | HSD17B1 (0.49) | HDAC4HDAC2HDAC8BACE1ALDH1A1 | |
| Phosphoric Acid SCHEMBL5946352 | 0.88 | ESR2 (0.46) | HDAC4HDAC2HDAC8BACE1ALDH1A1 | |
| Phosphoric Acid SCHEMBL28392022 | 0.88 | ESR2 (0.46) | HDAC4HDAC2HDAC8BACE1ALDH1A1 | |
| SCHEMBL355552 | 0.88 | ALDH1A1 (0.55) | HDAC4HDAC2HDAC8BACE1ALDH1A1 | |
| Phosphoric Acid SCHEMBL28647423 | 0.88 | ALDH1A1 (0.54) | HDAC4HDAC2HDAC8BACE1ALDH1A1 | |
| Phosphoric Acid SCHEMBL1900203 | 0.81 | HDAC4 (0.46) | HDAC4HDAC2HDAC8BACE1BCL2L1 | |
| Phosphoric Acid SCHEMBL958094 | 0.81 | ALDH1A1 (0.56) | HDAC4HDAC2HDAC8BACE1ALDH1A1 | |
| Phosphoric Acid SCHEMBL5597060 | 0.81 | ALDH1A1 (0.56) | HDAC4HDAC2HDAC8BACE1ALDH1A1 | |
| Phosphoric Acid SCHEMBL9017459 | 0.80 | GAPDH (0.42) | HSD17B10HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022110392-A1 | HALOGEN-FREE FLAME RETARDANT HAVING GOOD FLAME RETARDANCY AND PROCESSIBILITY, AND FLAME-RETARDANT RESIN COMPOSITION | 浙江旭森非卤消烟阻燃剂有限公司 | 2022-06-02 | — | — | WO | claimed |
| CN-109486066-A | Water-proof thermal insulation material and preparation method thereof | 南京航空航天大学溧水仿生产业研究院有限公司 | 2019-03-19 | — | — | CN | claimed |
| CN-108641331-A | A kind of lower shrinkage, high thermal stability anti-impact PC-ABS composite material and preparation methods | 芜湖创科新材料科技有限公司 | 2018-10-12 | — | — | CN | claimed |
| CN-108504063-A | Halogen-free flame retardant PC/CF composite materials and products thereof | 汉达精密电子(昆山)有限公司 | 2018-09-07 | — | — | CN | claimed |
| CN-107722586-A | CNT polycarbafil/carbon fibre composite and its products formed | 汉达精密电子(昆山)有限公司 | 2018-02-23 | — | — | CN | claimed |
| CN-110139883-A | Multi-layer decorative coating composition with low discoloration | SIKA技术股份公司 | 2019-08-16 | — | — | CN | disclosed |
| CN-106065176-B | A kind of halogen-free flame-retardant polyamide composition | 上海安凸塑料添加剂有限公司 | 2018-10-12 | — | — | CN | disclosed |
| CN-106065176-A | A kind of halogen-free flame-retardant polyamide composition | 上海安凸塑料添加剂有限公司 | 2016-11-02 | — | — | CN | disclosed |
| EP-2776499-A2 | P-N-COMPOUNDS AS FLAME RETARDANTS | BASF SE (DE) | 2014-09-17 | — | — | EP | disclosed |
| CN-102732984-B | Preparation method of permanent antistatic flame retardation multicolor polypropylene bulked filament | CHANGZHOU LINGDA CHEMICAL CO LTD | 2013-12-18 | — | — | CN | disclosed |
| WO-2013068437-A2 | P-N-COMPOUNDS AS FLAME RETARDANTS | BASF SE (DE) | 2013-05-16 | — | — | WO | disclosed |
| CN-102732984-A | Preparation method of permanent antistatic flame retardation multicolor polypropylene bulked filament | CHANGZHOU LINGDA CHEMICAL CO LTD | 2012-10-17 | — | — | CN | disclosed |
| CN-1326926-C | Titanium dioxide for incorporation into thermoplastic resin composition, and molded article thereof | IDEMITSU PETROCHEMICAL CO (JP) | 2007-07-18 | — | — | CN | disclosed |
| CN-1711315-A | Titanium dioxide for incorporation into thermoplastic resin composition, and molded article thereof | IDEMITSU PETROCHEMICAL CO (JP) | 2005-12-21 | — | — | CN | disclosed |