SCHEMBL14939161

SCHEMBL14939161

CCc1ccc(F)cc1CN1CCC(C2(c3cccc(C)c3)Cc3ccccc3C2=O)CC1

nearest known ligand 0.40

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
CXCR3 P49682 3/20 0.38
DRD2 P14416 5/20 0.36
DRD4 P21917 3/20 0.36
CHRM2 P08172 3/20 0.35
CHRM3 P20309 3/20 0.35
HTR2A P28223 2/20 0.35
HTR2C P28335 2/20 0.35
HTR2B P41595 2/20 0.35
SIGMAR1 Q99720 2/20 0.35
HTR7 P34969 1/20 0.34
CXCR4 P61073 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14939988 0.93 CXCR3 (0.44) ALDH1A1TDP1CXCR3DRD2HTR2A
SCHEMBL14939041 0.91 HTR7 (0.40) ALDH1A1CXCR3CHRM2CHRM3HTR7
SCHEMBL14938853 0.86 CXCR4 (0.48) ALDH1A1DRD2DRD4CHRM2CHRM3
SCHEMBL14939665 0.86 ACHE (0.44) ALDH1A1CXCR3DRD2DRD4CHRM2
SCHEMBL14939163 0.86 ACHE (0.44) ALDH1A1CXCR3DRD2DRD4CHRM2
SCHEMBL14940366 0.86 ACHE (0.44) ALDH1A1CXCR3DRD2DRD4CHRM2
SCHEMBL14938989 0.85 HTR7 (0.37) ALDH1A1CXCR3DRD2DRD4CHRM2
SCHEMBL14940471 0.84 CXCR3 (0.48) CXCR3DRD2CHRM2CHRM3HTR2A
SCHEMBL14939601 0.84 ALDH1A1 (0.46) ALDH1A1TDP1CXCR3
SCHEMBL14939344 0.80 CHRM2 (0.52) ALDH1A1CXCR3DRD2DRD4CHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013068785-A1 INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS ACTELION PHARMACEUTICALS LTD (CH) 2013-05-16 WO claimed
WO-2013068785-A1 INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS ACTELION PHARMACEUTICALS LTD (CH) 2013-05-16 WO disclosed