Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | NSD2 | O96028 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | GALK1 | P51570 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 2/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14938952 | 0.83 | CDK5 (0.40) | MAPTCFTRGOPCGAARAB9A | |
| SCHEMBL14938950 | 0.81 | SRD5A1 (0.36) | MAPTCFTRGOPCGAARAB9A | |
| SCHEMBL14939135 | 0.81 | ALDH1A1 (0.40) | MAPTKDM4EDAOCFTRGOPC | |
| SCHEMBL14939637 | 0.78 | ACHE (0.43) | MAPTKDM4ERAB9AGSK3BKMT2A | |
| SCHEMBL14938940 | 0.75 | NPSR1 (0.49) | MAPTTDP2CES1CFTRGOPC | |
| SCHEMBL9495505 | 0.71 | BLM (0.38) | MAPTNSD2KDM4EAPAF1TDP2 | |
| SCHEMBL14939783 | 0.70 | CASP6 (0.40) | MAPTNPSR1KMT2A | |
| SCHEMBL29237769 | 0.69 | NSD2 (0.36) | MAPTNSD2KDM4EAPAF1TDP2 | |
| SCHEMBL14939719 | 0.69 | KDM1A (0.36) | CES1GSK3B | |
| SCHEMBL14939587 | 0.68 | NSD2 (0.39) | MAPTNSD2KDM4EAPAF1TDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |