SCHEMBL14948276

SCHEMBL14948276

c1ccc([Si](c2ccccc2)(c2cccc(-c3nccc4c3sc3ccccc34)c2)c2ccc3c4ccccc4c4ccccc4c3c2)cc1

nearest known ligand 0.34

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TNKS O95271 1/20 0.34
TNKS2 Q9H2K2 1/20 0.34
ALOX5 P09917 1/20 0.34
TDO2 P48775 6/20 0.32
IDO1 P14902 1/20 0.32
PDE3B Q13370 1/20 0.31
PDE3A Q14432 1/20 0.31
HTR2B P41595 1/20 0.31
HTR5A P47898 1/20 0.31
MAPT P10636 1/20 0.31
LIMK1 P53667 2/20 0.30
BCHE P06276 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17754685 0.95 ALOX5 (0.43) TNKSTNKS2ALOX5TDO2LIMK1
SCHEMBL26238249 0.94 TNKS (0.37) TNKSTNKS2ALOX5TDO2IDO1
SCHEMBL17754697 0.90 ALOX5 (0.46) TNKSTNKS2ALOX5TDO2IDO1
SCHEMBL17754701 0.89 KDM4E (0.31)
SCHEMBL17754693 0.88 ALOX5 (0.43) TNKSTNKS2ALOX5TDO2LIMK1
SCHEMBL17754688 0.88 ALOX5 (0.47) TNKSTNKS2ALOX5TDO2IDO1
SCHEMBL17754703 0.84 KDM4E (0.33) TNKSTNKS2ALOX5MAPT
SCHEMBL17754637 0.83 ALOX5 (0.51) TNKSTNKS2ALOX5TDO2MAPT
SCHEMBL14948266 0.83 ALOX5 (0.51) TNKSTNKS2ALOX5TDO2MAPT
SCHEMBL17754702 0.83 KDM4E (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11647669-B2 Heterocyclic compound and organic light-emitting device including the same SAMSUNG DISPLAY CO., LTD. (KR) 2023-05-09 US disclosed
US-9142788-B2 Host materials for OLEDs UNIVERSAL DISPLAY CORPORATION (US) 2015-09-22 US disclosed
US-9142788-B2 Host materials for OLEDs UNIVERSAL DISPLAY CORPORATION (US) 2015-09-22 US disclosed
US-8652656-B2 Triphenylene silane hosts UNIVERSAL DISPLAY CORPORATION (US) 2014-02-18 US disclosed
US-8652656-B2 Triphenylene silane hosts UNIVERSAL DISPLAY CORPORATION (US) 2014-02-18 US disclosed
US-20130119353-A1 TRIPHENYLENE SILANE HOSTS UNIVERSAL DISPLAY CORPORATION (US) 2013-05-16 US disclosed
US-20130119353-A1 TRIPHENYLENE SILANE HOSTS UNIVERSAL DISPLAY CORPORATION (US) 2013-05-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11647669-B2 Heterocyclic compound and organic light-emitting device including the same CRY1, CYP1A1, CRY2 TNKS 2356/4885TNKS2 2972/4885ALOX5 1009/4885
US-20130119353-A1 TRIPHENYLENE SILANE HOSTS OCIAD2, OCIAD1, YAP1 TNKS 1795/4885TNKS2 1811/4885ALOX5 738/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.