Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SREBF2 | Q12772 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17832058 | 0.87 | NOS3 (0.46) | KDM4EALDH1A1SREBF2HDAC3HDAC1 | |
| SCHEMBL15409505 | 0.84 | KDM4E (0.41) | KDM4EALDH1A1HDAC3HDAC1HDAC2 | |
| SCHEMBL14945524 | 0.83 | KDM4E (0.35) | KDM4EALDH1A1 | |
| SCHEMBL17123710 | 0.78 | UHRF1 (0.41) | KDM4EALDH1A1NOS2NOS3NOS1 | |
| SCHEMBL487201 | 0.77 | KDM4E (0.56) | KDM4ELMNACYP3A4TSHRALDH1A1 | |
| SCHEMBL2619306 | 0.75 | CYP1A2 (0.47) | KDM4ELMNACYP3A4TSHRSREBF2 | |
| SCHEMBL15284970 | 0.75 | ALDH1A1 (0.39) | KDM4EALDH1A1MAPTL3MBTL1HTR2C | |
| SCHEMBL14068446 | 0.75 | KDM4E (0.39) | KDM4EALDH1A1HTR2CSLC6A4 | |
| SCHEMBL27592196 | 0.75 | KDM4E (0.42) | KDM4EALDH1A1 | |
| SCHEMBL15285044 | 0.74 | NOS2 (0.53) | KDM4ELMNAALDH1A1NOS2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160168205-A1 | METHODS AND COMPOSITIONS FOR LABELING POLYPEPTIDES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-06-16 | — | — | US | disclosed |
| US-9212381-B2 | Methods and compositions for labeling polypeptides | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-12-15 | — | — | US | disclosed |
| US-20130122535-A1 | METHODS AND COMPOSITIONS FOR LABELING POLYPEPTIDES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168205-A1 | METHODS AND COMPOSITIONS FOR LABELING POLYPEPTIDES | NPEPPS, PSMG3, PSMA6 | KDM4E 2762/4885LMNA 1366/4885CYP3A4 4673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.