Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5461176 | 0.81 | CA2 (0.33) | CYP11B2CYP11B1 | |
| SCHEMBL12482370 | 0.79 | LOXL2 (0.35) | CYP11B2 | |
| SCHEMBL4906652 | 0.79 | ALDH1A1 (0.37) | CYP11B2PRMT5WDR77ALDH1A1LMNA | |
| SCHEMBL29955560 | 0.79 | ALDH1A1 (0.37) | CYP11B2PRMT5WDR77ALDH1A1LMNA | |
| SCHEMBL29952117 | 0.79 | ALDH1A1 (0.31) | MEN1ALDH1A1KMT2A | |
| SCHEMBL29956119 | 0.79 | LOXL2 (0.35) | CYP11B2 | |
| SCHEMBL29318108 | 0.79 | — | — | |
| SCHEMBL29066265 | 0.78 | MKNK1 (0.49) | CYP11B2CYP11B1PRMT5WDR77PTGS2 | |
| SCHEMBL2728918 | 0.77 | CYP2A6 (0.47) | CYP2A6CYP11B2CYP11B1KDM4EDYRK1A | |
| SCHEMBL1663512 | 0.77 | ALDH1A1 (0.36) | CYP2A6KDM4EPTGS2RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111527079-B | 2- [5- (imidazol-1-ylmethyl) pyridin-3-yl ] benzimidazole derivative compound and medicament containing the same | 日本医事物理股份有限公司 | 2023-08-11 | — | — | CN | disclosed |
| EP-3733661-B1 | 2-[5-(IMIDAZOLE-1-YLMETHYL)PYRIDINE-3-YL]BENZIMIDAZOLE DERIVATIVE COMPOUND, AND MEDICINE INCLUDING SAME | NIHON MEDIPHYSICS CO LTD (JP) | 2023-03-15 | — | — | EP | disclosed |
| US-11266753-B2 | 2-[5-(imidazol-1-ylmethyl)pyridin-3-yl]benzimtdazole derivative compound, and medicament including same | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2022-03-08 | — | — | US | disclosed |
| US-20210060186-A1 | 2-[5-(IMIDAZOL-1-YLMETHYL)PYRIDIN-3-YL]BENZIMIDAZOLE DERIVATIVE COMPOUND, AND MEDICAMENT INCLUDING SAME | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2021-03-04 | — | — | US | disclosed |
| US-20210060186-A1 | 2-[5-(IMIDAZOL-1-YLMETHYL)PYRIDIN-3-YL]BENZIMIDAZOLE DERIVATIVE COMPOUND, AND MEDICAMENT INCLUDING SAME | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2021-03-04 | — | — | US | disclosed |
| EP-3733661-A1 | 2-[5-(IMIDAZOLE-1-YLMETHYL)PYRIDINE-3-YL]BENZIMIDAZOLE DERIVATIVE COMPOUND, AND MEDICINE INCLUDING SAME | Nihon Medi-Physics Co., Ltd (JP) | 2020-11-04 | — | — | EP | disclosed |
| EP-3162802-B1 | 2-(3-PYRIDINYL)-1H-BENZIMIDAZOLE DERIVATIVE COMPOUND AND MEDICINE CONTAINING SAME | NIHON MEDIPHYSICS CO LTD (JP) | 2020-08-19 | — | — | EP | disclosed |
| EP-3162802-B1 | 2-(3-PYRIDINYL)-1H-BENZIMIDAZOLE DERIVATIVE COMPOUND AND MEDICINE CONTAINING SAME | NIHON MEDIPHYSICS CO LTD (JP) | 2020-08-19 | — | — | EP | disclosed |
| CN-111527079-A | 2- [5- (imidazol-1-ylmethyl) pyridin-3-yl ] benzimidazole derivative compound and medicine comprising the same | 日本医事物理股份有限公司 | 2020-08-11 | — | — | CN | disclosed |
| WO-2020085238-A1 | SALT OF RADIOACTIVE FLUORINE-LABELED PRECURSOR COMPOUND | 日本メジフィジックス株式会社 | 2020-04-30 | — | — | WO | disclosed |
| EP-3162802-A1 | 2-(3-PYRIDINYL)-1H-BENZIMIDAZOLE DERIVATIVE COMPOUND AND MEDICINE CONTAINING SAME | Nihon Medi-Physics Co., Ltd. (JP) | 2017-05-03 | — | — | EP | disclosed |
| EP-3162802-A1 | 2-(3-PYRIDINYL)-1H-BENZIMIDAZOLE DERIVATIVE COMPOUND AND MEDICINE CONTAINING SAME | Nihon Medi-Physics Co., Ltd. (JP) | 2017-05-03 | — | — | EP | disclosed |
| US-9637491-B2 | Pyrazolo[4,3-D]pyrimidines as kinase inhibitors | ORIGENIS GMBH (DE) | 2017-05-02 | — | — | US | disclosed |
| CN-106458995-A | 2-(3-pyridinyl)-1H-benzimidazole derivative compound and medicine containing same | 日本医事物理股份有限公司 | 2017-02-22 | — | — | CN | disclosed |
| WO-2015199205-A1 | 2-(3-PYRIDINYL)-1H-BENZIMIDAZOLE DERIVATIVE COMPOUND AND MEDICINE CONTAINING SAME | 日本メジフィジックス株式会社 | 2015-12-30 | — | — | WO | disclosed |
| US-9212138-B2 | Use of derivatives of indoles for the treatment of cancer | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2015-12-15 | — | — | US | disclosed |
| US-20150266882-A1 | PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2015-09-24 | — | — | US | disclosed |
| US-20140235654-A1 | USE OF DERIVATIVES OF INDOLES FOR THE TREATMENT OF CANCER | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2014-08-21 | — | — | US | disclosed |
| WO-2014060112-A1 | PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2014-04-24 | — | — | WO | disclosed |
| US-20130131084-A1 | USE OF DERIVATIVES OF INDOLES FOR THE TREATMENT OF CANCER | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2013-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266882-A1 | PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS | LRRK2, MYLK2, MYLK | CYP2A6 3749/4885CYP11B2 1788/4885CYP11B1 1981/4885 |
| US-20210060186-A1 | 2-[5-(IMIDAZOL-1-YLMETHYL)PYRIDIN-3-YL]BENZIMIDAZOLE DERIVATIVE COMPOUND, AND MEDICAMENT INCLUDING SAME | NPM1, ABL1, FLI1 | CYP2A6 1579/4885CYP11B2 72/4885CYP11B1 167/4885 |
| US-20140235654-A1 | USE OF DERIVATIVES OF INDOLES FOR THE TREATMENT OF CANCER | IDO1, IDO2, INMT | CYP2A6 466/4885CYP11B2 51/4885CYP11B1 70/4885 |
| US-20130131084-A1 | USE OF DERIVATIVES OF INDOLES FOR THE TREATMENT OF CANCER | IDO1, IDO2, INMT | CYP2A6 466/4885CYP11B2 51/4885CYP11B1 70/4885 |
| US-11266753-B2 | 2-[5-(imidazol-1-ylmethyl)pyridin-3-yl]benzimtdazole derivative compound, and medicament including same | NPM1, XDH, ABL1 | CYP2A6 1236/4885CYP11B2 17/4885CYP11B1 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.