Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.37 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 6/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 7/20 | 0.34 |
| ▸ | NPC1 | O15118 | 7/20 | 0.34 |
| ▸ | RAB9A | P51151 | 6/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.31 |
| ▸ | RELA | Q04206 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14964289 | 0.85 | MAPT (0.38) | KMT2AMAPTALDH1A1HTR1ATP53 | |
| SCHEMBL16581976 | 0.83 | MAOB (0.36) | MEN1KMT2AGAAMAPTALDH1A1 | |
| SCHEMBL16581662 | 0.82 | MEN1 (0.34) | MEN1KMT2AGAAMAPTLMNA | |
| SCHEMBL14964338 | 0.82 | IDO1 (0.35) | MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL14462329 | 0.81 | LMNA (0.44) | SENP2SENP1MEN1KMT2AGAA | |
| SCHEMBL14964328 | 0.81 | IDO1 (0.37) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL15093214 | 0.80 | ALDH1A1 (0.34) | SMN1; SMN2LMNAALDH1A1USP2 | |
| SCHEMBL14964314 | 0.79 | CA2 (0.54) | MEN1KMT2A | |
| SCHEMBL15093027 | 0.79 | MAPT (0.36) | MEN1KMT2AGAAMAPTSMN1; SMN2 | |
| SCHEMBL14964308 | 0.78 | IDO1 (0.33) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |