Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
| ▸ | F9 | P00740 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16581976 | 0.92 | MAOB (0.36) | MAPTTDP1ALDH1A1MAPK1HTT | |
| SCHEMBL14964220 | 0.85 | SENP2 (0.37) | MAPTALDH1A1HTTTP53HTR1A | |
| SCHEMBL16581662 | 0.85 | MEN1 (0.34) | MAPTALDH1A1HTTTP53KMT2A | |
| SCHEMBL14964314 | 0.82 | CA2 (0.54) | MAOBKMT2A | |
| SCHEMBL14462310 | 0.81 | MAPT (0.42) | MAPTTDP1ALDH1A1MAPK1HTT | |
| SCHEMBL14964338 | 0.81 | IDO1 (0.35) | ALDH1A1IDO1KMT2A | |
| SCHEMBL14964328 | 0.80 | IDO1 (0.37) | ALDH1A1IDO1 | |
| SCHEMBL15093214 | 0.79 | ALDH1A1 (0.34) | ALDH1A1IDO1 | |
| SCHEMBL15093027 | 0.79 | MAPT (0.36) | MAPTALDH1A1HTTTP53IDO1 | |
| SCHEMBL14964308 | 0.77 | IDO1 (0.33) | ALDH1A1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |