Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14964194 | 0.83 | SMN1; SMN2 (0.37) | NPC1RAB9ASMN1; SMN2GRIN1GRIN2A | |
| SCHEMBL14462659 | 0.83 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2MAPTLMNA | |
| Trifluoroacetic Acid SCHEMBL15093526 | 0.80 | IDO1 (0.32) | SMN1; SMN2MAPTLMNAIDO1HTT | |
| SCHEMBL14964338 | 0.79 | IDO1 (0.35) | SMN1; SMN2IDO1KMT2AMEN1 | |
| SCHEMBL4979731 | 0.79 | IDO1 (0.34) | MAPTLMNAIDO1HTTKMT2A | |
| Trifluoroacetic Acid SCHEMBL15093217 | 0.79 | SMN1; SMN2 (0.34) | NPC1RAB9ASMN1; SMN2LMNAIDO1 | |
| SCHEMBL14964340 | 0.79 | SIGMAR1 (0.36) | RAB9ASMN1; SMN2LMNAIDO1HTT | |
| SCHEMBL4971385 | 0.79 | ALDH1A1 (0.38) | NPC1RAB9ASMN1; SMN2MAPTLMNA | |
| SCHEMBL14964361 | 0.79 | POLB (0.46) | NPC1RAB9ASMN1; SMN2MAPTLMNA | |
| SCHEMBL14964328 | 0.78 | IDO1 (0.37) | SMN1; SMN2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |