Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14964194 | 0.87 | SMN1; SMN2 (0.37) | POLBNPC1LMNAUSP2KMT2A | |
| SCHEMBL15100408 | 0.83 | NPC1 (0.55) | POLBNPC1LMNAKMT2AMEN1 | |
| SCHEMBL4979731 | 0.82 | IDO1 (0.34) | LMNAKMT2AMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL14964214 | 0.80 | ALDH1A1 (0.33) | POLBLMNAKMT2AMEN1L3MBTL1 | |
| SCHEMBL14964340 | 0.80 | SIGMAR1 (0.36) | LMNAKMT2AMEN1RAB9AALDH1A1 | |
| SCHEMBL4980217 | 0.80 | TAAR1 (0.35) | NPC1LMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL14964279 | 0.79 | IDO1 (0.33) | — | |
| SCHEMBL14964338 | 0.79 | IDO1 (0.35) | KMT2AMEN1ALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL4973610 | 0.79 | NPC1 (0.54) | POLBNPC1LMNAKMT2AMEN1 | |
| SCHEMBL5631091 | 0.79 | NPC1 (0.54) | POLBNPC1LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |