Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 12/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.33 |
| ▸ | FLT3 | P36888 | 3/20 | 0.33 |
| ▸ | CDK9 | P50750 | 3/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.33 |
| ▸ | RPS6KA6 | Q9UK32 | 3/20 | 0.33 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 3/20 | 0.33 |
| ▸ | JAK1 | P23458 | 3/20 | 0.33 |
| ▸ | TYK2 | P29597 | 3/20 | 0.33 |
| ▸ | JAK3 | P52333 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965652 | 0.90 | GPR119 (0.38) | LRRK2METJAK2JAK1TYK2 | |
| SCHEMBL14966211 | 0.88 | MTOR (0.38) | METTBK1 | |
| SCHEMBL14965835 | 0.88 | MTOR (0.37) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL14965574 | 0.88 | HDAC4 (0.36) | METTBK1 | |
| SCHEMBL14965806 | 0.88 | MET (0.39) | METJAK2JAK1TYK2JAK3 | |
| SCHEMBL14965517 | 0.86 | FGFR1 (0.40) | MET | |
| SCHEMBL14965570 | 0.86 | JAK2 (0.36) | LRRK2METJAK2JAK1TYK2 | |
| SCHEMBL14965678 | 0.84 | MTOR (0.37) | — | |
| SCHEMBL14966317 | 0.82 | LOXL2 (0.42) | JAK2JAK3HTR1ADRD2 | |
| SCHEMBL14965683 | 0.82 | DRD2 (0.43) | HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | claimed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |