Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 8/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965806 | 0.94 | MET (0.39) | MTORJAK2JAK1TYK2JAK3 | |
| SCHEMBL14965820 | 0.90 | JAK2 (0.37) | MTORJAK2JAK1TYK2JAK3 | |
| SCHEMBL14965666 | 0.88 | LRRK2 (0.36) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL14965574 | 0.88 | HDAC4 (0.36) | PIK3CA | |
| SCHEMBL14966211 | 0.87 | MTOR (0.38) | MTORPIK3CA | |
| SCHEMBL14965517 | 0.86 | FGFR1 (0.40) | ALDH1A1 | |
| SCHEMBL14966353 | 0.86 | JAK2 (0.37) | JAK2JAK1TYK2JAK3LMNA | |
| SCHEMBL14966081 | 0.84 | KCNJ1 (0.39) | MTORJAK2JAK1TYK2JAK3 | |
| SCHEMBL14965844 | 0.84 | LMNA (0.35) | JAK2JAK1TYK2JAK3LMNA | |
| SCHEMBL14966238 | 0.83 | MET (0.41) | MTORJAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | claimed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |