Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.36 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.36 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966121 | 0.93 | BRD4 (0.46) | BRD4NPBWR1ADORA2APTGS2PKM | |
| SCHEMBL3387257 | 0.81 | BRD4 (0.48) | BRD4HDAC1HDAC2PKM | |
| SCHEMBL14966246 | 0.80 | GLS (0.44) | BRD4PTGS2PDE4A | |
| SCHEMBL5863449 | 0.80 | ALDH1A1 (0.48) | ALDH1A1KDM4EHSD17B10NPC1RAB9A | |
| SCHEMBL27083872 | 0.78 | HDAC1 (0.51) | BRD4HDAC1HDAC2ADORA2APKM | |
| SCHEMBL14965879 | 0.75 | PTGS2 (0.37) | PTGS2PKMALDH1A1TDP1KDM4E | |
| SCHEMBL14965797 | 0.75 | CNR2 (0.42) | BRD4NPBWR1PTGS2PDE1APDE1B | |
| SCHEMBL5863967 | 0.74 | TDP1 (0.56) | BRD4PKMALDH1A1TDP1KDM4E | |
| SCHEMBL20325546 | 0.72 | HDAC1 (0.47) | BRD4HDAC1HDAC2NPBWR1ADORA2A | |
| SCHEMBL14965757 | 0.72 | KDM4E (0.40) | ALDH1A1TDP1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072825-A1 | PHTALAZINONE DERIVATIVES AS MPEGS -1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013072825-A1 | PHTALAZINONE DERIVATIVES AS MPEGS -1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-05-23 | — | — | WO | disclosed |