SCHEMBL1496945

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL1496893	0.93	POLB (0.37)	RAF1ROCK1SMN1; SMN2HDAC1ROCK2
	SCHEMBL1496862	0.92	HTR5A (0.40)	HIF1ARAF1ROCK1MEN1KMT2A
	SCHEMBL12831883	0.90	RAF1 (0.37)	HIF1AKDM4ERAF1ROCK1HDAC1
	SCHEMBL1497043	0.88	HIF1A (0.42)	HIF1AHDAC1ROCK2HTR5A
	SCHEMBL1496875	0.88	HTR5A (0.39)	ROCK1MEN1KMT2AHDAC3HDAC1
	SCHEMBL1496860	0.88	ROCK2 (0.38)	RAF1ROCK1KMT2AHDAC3HDAC1
	SCHEMBL1496843	0.87	KMT2A (0.40)	RAF1ROCK1SMN1; SMN2MEN1KMT2A
	SCHEMBL1496892	0.87	CTSK (0.38)	HIF1AKDM4EROCK1MEN1KMT2A
	SCHEMBL1497058	0.87	HIF1A (0.44)	HIF1ARAF1ROCK1IDO1MAOB
	SCHEMBL1497447	0.87	HDAC1 (0.35)	RAF1ROCK1HDAC3HDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.